Heim / Peptid-Wiki / VIP (Vasoaktives intestinales Peptid)
Immun

VIP (Vasoaktives intestinales Peptid)

Immunmodulator

Endogenous neuropeptide with potent immunomodulatory, anti-inflammatory, and vasodilatory properties. Regulates circadian biology, gut motility, and T-regulatory cell activity. Used in autoimmunity, CIRS, and long COVID research.

Aminosäuren28
Mol. Gewicht3326.8 Da
Halbwertszeit~1–2 Minuten (Plasma)
Verfügbarkeit 🔔 Auf Anfrage
Aminosäuresequenz His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH₂

What Is VIP?

Vasoactive Intestinal Peptide (VIP) is a 28-amino-acid neuropeptide found throughout the nervous and immune systems. It acts via VPAC1 and VPAC2 receptors and has potent anti-inflammatory, vasodilatory, and neurotropic properties. It is a key regulator of circadian clock gene expression in the suprachiasmatic nucleus.

Schlüsselmechanismen

  • VPAC1/2 receptor activation — cAMP-mediated anti-inflammatory and vasodilatory effects
  • Treg induction — promotes FoxP3+ T-regulatory cell differentiation; suppresses autoimmune responses
  • Th1/Th17 suppression — reduces IFN-γ, TNF-α, IL-6, IL-17 production
  • Circadian regulation — drives synchronous circadian oscillation in SCN neurons
  • Gut motility — inhibits smooth muscle contraction; stimulates intestinal secretion

Wichtige Referenzen

  1. Delgado M et al. “Vasoactive intestinal peptide: a neuropeptide with pleiotropic immune functions.” Cell Mol Life Sci, 2004;61(7-8):838–850.
🔬

Peptid anfordern

Füllen Sie das Formular aus, und wir melden uns innerhalb von 24 Stunden bei Ihnen.