{"id":878,"date":"2026-04-23T23:49:30","date_gmt":"2026-04-23T23:49:30","guid":{"rendered":"https:\/\/decodepeptides.com\/?product=nad-plus"},"modified":"2026-05-29T01:10:58","modified_gmt":"2026-05-29T01:10:58","slug":"nad-plus","status":"publish","type":"product","link":"https:\/\/decodepeptides.com\/de\/product\/nad-plus\/","title":{"rendered":"NAD+ 100 mg"},"content":{"rendered":"

NAD+<\/strong> (Nicotinamide Adenine Dinucleotide) is the central electron carrier of cellular metabolism and the obligate substrate for sirtuins (SIRT1\u20137), PARPs, and CD38 \u2014 three enzyme families that together regulate DNA repair, mitochondrial efficiency, circadian biology, inflammatory response, and metabolic homeostasis. NAD+ levels decline by approximately 50% between ages 40 and 60, a decline now considered one of the primary molecular drivers of biological aging. Direct NAD+ supplementation is the gold-standard research tool for studying sirtuin activation, mitochondrial rejuvenation, and DNA repair kinetics in aging models.<\/p>\n

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\u226599%<\/span>HPLC-Reinheit<\/span><\/div>\n
100mg<\/span>Von Vial<\/span><\/div>\n
80+<\/span>Jahre der Recherche<\/span><\/div>\n
Coenzym<\/span>Struktur<\/span><\/div>\n<\/div>\n
\"NAD+\"NAD+<\/div>\n

Forschungsdaten<\/span><\/p>\n

Research Snapshot \u2014 NAD+<\/h2>\n

Schl\u00fcsselmechanismen und Signalwege<\/h3>\n
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  • Sirtuin Activation (SIRT1-7)<\/strong>All 7 sirtuins require NAD+ as obligate cofactor; SIRT1 activates PGC-1\u03b1 (mitochondrial biogenesis), SIRT3 maintains ETC, SIRT6 preserves genomic stability.<\/li>\n
  • PARP-Mediated DNA Repair<\/strong>PARP1\/2 consume NAD+ to repair up to 70,000 single-strand DNA breaks per cell per day via poly(ADP-ribose) synthesis.<\/li>\n
  • Complex I Electron Transport<\/strong>NADH (reduced NAD+) is the electron donor for Complex I \u2014 the rate-limiting step of mitochondrial ATP production.<\/li>\n
  • CD38 Competition<\/strong>CD38 NADase expression rises with age\/inflammation (inflammaging); NAD+ repletion offsets this consumption and restores sirtuin activity.<\/li>\n
  • AMPK Cross-Talk<\/strong>Via SIRT1 \u2192 LKB1 \u2192 AMPK signalling, elevated NAD+ promotes repair and catabolic states \u2014 the metabolic signature of longevity.<\/li>\n
  • Circadian Clock Regulation<\/strong>SIRT1 deacetylates BMAL1 and PER2 \u2014 core clock proteins \u2014 linking NAD+ levels directly to circadian rhythm quality.<\/li>\n<\/ul>\n

    Zusammenfassung der pr\u00e4klinischen und klinischen Forschung<\/h3>\n\n\n\n\n\n\n\n\n
    Forschungsgebiet<\/th>\nWichtigste Erkenntnis<\/th>\nQuelle<\/th>\n<\/tr>\n<\/thead>\n
    Muscle Rejuvenation<\/td>\nRestored muscle mass, strength and mitochondrial density in aged mice to levels of young controls.<\/td>\nGomes AP et al., 2013 \u2014 Cell<\/td>\n<\/tr>\n
    DNA Repair Restoration<\/td>\nReversed \u03b3H2AX\/8-OHdG DNA damage markers; improved radiation survival in aged mice.<\/td>\nLi J et al., 2017 \u2014 Science<\/td>\n<\/tr>\n
    Stoffwechselgesundheit<\/td>\nNAD+ precursor NMN improved glucose tolerance, lipid metabolism and energy expenditure in obese mice.<\/td>\nYoshino J et al., 2011 \u2014 Cell Metab<\/td>\n<\/tr>\n
    Human Clinical Trial<\/td>\n250mg NMN\/day for 10 weeks increased skeletal muscle NAD+ and improved insulin sensitivity in prediabetic women.<\/td>\nYoshino M et al., 2021 \u2014 Science<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
    \n

    Referenzen<\/h3>\n
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    1. Gomes AP et al. “Declining NAD+ induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging.” Cell<\/em>, 2013;155(7):1624\u20131638.<\/li>\n
    2. Yoshino J et al. “Nicotinamide mononucleotide, a key NAD+ intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice.” Cell Metab<\/em>, 2011;14(4):528\u2013536.<\/li>\n
    3. Verdin E. “NAD+ in aging, metabolism, and neurodegeneration.” Science<\/em>, 2015;350(6265):1208\u20131213.<\/li>\n
    4. Yoshino M et al. “Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women.” Science<\/em>, 2021;372(6547):1224\u20131229.<\/li>\n<\/ol>\n<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"

      NAD+ (Nicotinamide Adenine Dinucleotide) is an essential coenzyme found in every living cell, serving as a fundamental electron carrier in cellular energy metabolism and a critical substrate for sirtuins, PARP enzymes, and CD38. NAD+ levels decline dramatically with age \u2014 by up to 50% between ages 40 and 60 \u2014 making it one of the most studied molecules in longevity and aging research. Each vial contains 100mg of pharmaceutical-grade NAD+.<\/p>","protected":false},"featured_media":2121,"comment_status":"open","ping_status":"closed","template":"","meta":{"inline_featured_image":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0},"product_brand":[],"product_cat":[56],"product_tag":[213,227,218,216,256,214,254,225,226,255],"class_list":["post-878","product","type-product","status-publish","has-post-thumbnail","product_cat-anti-aging-longevity","product_tag-anti-aging","product_tag-energy-production","product_tag-cellular-senescence","product_tag-dna-repair","product_tag-hplc-verified","product_tag-longevity","product_tag-lyophilized-powder","product_tag-mitochondrial-health","product_tag-nad-plus","product_tag-research-grade","first","instock","shipping-taxable","purchasable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/decodepeptides.com\/de\/wp-json\/wp\/v2\/product\/878","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/decodepeptides.com\/de\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/decodepeptides.com\/de\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/decodepeptides.com\/de\/wp-json\/wp\/v2\/comments?post=878"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/decodepeptides.com\/de\/wp-json\/wp\/v2\/media\/2121"}],"wp:attachment":[{"href":"https:\/\/decodepeptides.com\/de\/wp-json\/wp\/v2\/media?parent=878"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/decodepeptides.com\/de\/wp-json\/wp\/v2\/product_brand?post=878"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/decodepeptides.com\/de\/wp-json\/wp\/v2\/product_cat?post=878"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/decodepeptides.com\/de\/wp-json\/wp\/v2\/product_tag?post=878"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}