{"id":872,"date":"2026-04-23T23:49:24","date_gmt":"2026-04-23T23:49:24","guid":{"rendered":"https:\/\/decodepeptides.com\/?product=epithalon-10mg"},"modified":"2026-05-29T01:10:58","modified_gmt":"2026-05-29T01:10:58","slug":"epithalon-10mg","status":"publish","type":"product","link":"https:\/\/decodepeptides.com\/de_at\/product\/epithalon-10mg\/","title":{"rendered":"Epithalon 10mg"},"content":{"rendered":"

Epithalon<\/strong> (tetrapeptide Ala-Glu-Asp-Gly) was developed by Professor Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology from pineal gland extract. It is one of the best-documented anti-aging peptides in the world, with over 30 years of peer-reviewed research demonstrating direct telomerase activation, epigenetic reprogramming of senescent cells, melatonin restoration, and significant lifespan extension in multiple model organisms. Its ability to increase telomere length in human somatic cells makes it the leading research tool for telomere biology and biological age reversal studies.<\/p>\n

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\u226599%<\/span>HPLC Purity<\/span><\/div>\n
10mg<\/span>Per Vial<\/span><\/div>\n
30+<\/span>Years Researched<\/span><\/div>\n
4 aa<\/span>Structure<\/span><\/div>\n<\/div>\n
\"Epithalon\"Epithalon<\/div>\n

Research Data<\/span><\/p>\n

Research Snapshot \u2014 Epithalon<\/h2>\n

Key Mechanisms & Pathways<\/h3>\n
    \n
  • Telomerase (hTERT) Activation<\/strong>Directly upregulates telomerase, extending telomeric DNA repeats and reversing cellular senescence.<\/li>\n
  • Pineal Gland Normalisation<\/strong>Restores melatonin synthesis in aged pinealocytes, resetting circadian and immune regulation.<\/li>\n
  • Antioxidant Gene Upregulation<\/strong>Increases SOD, catalase and glutathione peroxidase \u2014 the primary enzymatic antioxidant defence system.<\/li>\n
  • Epigenetic Reprogramming<\/strong>Reactivates methylation-silenced tumour suppressor genes p16 and p21.<\/li>\n
  • Neuroendocrine Axis Reset<\/strong>Restores hypothalamic receptor sensitivity to sex steroid feedback, normalising age-related hormonal decline.<\/li>\n
  • NK Cell Activation<\/strong>Enhanced natural killer cell cytotoxicity and restored thymic activity in aged rodent models.<\/li>\n<\/ul>\n

    Preclinical & Clinical Research Summary<\/h3>\n\n\n\n\n\n\n\n\n
    Research Area<\/th>\nKey Finding<\/th>\nSource<\/th>\n<\/tr>\n<\/thead>\n
    Telomere Elongation<\/td>\n+42% replicative lifespan of human fetal fibroblasts vs. controls via hTERT activation.<\/td>\nKhavinson et al., 2003 \u2014 Bull Exp Biol Med<\/td>\n<\/tr>\n
    Lifespan Extension<\/td>\nExtended Drosophila mean lifespan by 11\u201316%; maximum lifespan by 13%.<\/td>\nKhavinson et al., 2000 \u2014 Bull Exp Biol Med<\/td>\n<\/tr>\n
    Cancer Prevention<\/td>\nReduced spontaneous mammary tumour incidence by 2.4\u00d7 in HER2-transgenic mice.<\/td>\nAnisimov VN et al., 2003 \u2014 Biogerontology<\/td>\n<\/tr>\n
    Cardiovascular<\/td>\nReduced cardiovascular mortality in 12-year longitudinal study of elderly patients.<\/td>\nKhavinson et al., 2012 \u2014 Gerontology<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
    \n

    References<\/h3>\n
      \n
    1. Khavinson VKh et al. “Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells.” Bull Exp Biol Med<\/em>, 2003;135(6):590\u2013592.<\/li>\n
    2. Anisimov VN et al. “Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence.” Biogerontology<\/em>, 2003;4(4):193\u2013202.<\/li>\n
    3. Kossoy G et al. “Effect of epithalon on the lifespan and frequency of spontaneous mammary gland tumors in transgenic HER2 mice.” Neoplasma<\/em>, 2006;53(3):187\u2013192.<\/li>\n
    4. Khavinson V et al. “Tetrapeptide AEDG (Epitalon) inhibits oxidative stress.” Regul Toxicol Pharmacol<\/em>, 2014;70(1):289\u2013294.<\/li>\n<\/ol>\n<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"

      Epithalon (Epitalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) developed from the natural pineal peptide Epithalamin. It is one of the most extensively researched anti-aging peptides, studied primarily for its ability to stimulate telomerase activity, elongate telomeres, and regulate circadian rhythms. Each vial contains 10mg of research-grade Epithalon.<\/p>","protected":false},"featured_media":2115,"comment_status":"open","ping_status":"closed","template":"","meta":{"inline_featured_image":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0},"product_brand":[],"product_cat":[56],"product_tag":[213,218,216,217,256,214,254,211,255,215],"class_list":["post-872","product","type-product","status-publish","has-post-thumbnail","product_cat-anti-aging-longevity","product_tag-anti-aging","product_tag-cellular-senescence","product_tag-dna-repair","product_tag-epigenetic-reset","product_tag-hplc-verified","product_tag-longevity","product_tag-lyophilized-powder","product_tag-neuroprotection","product_tag-research-grade","product_tag-telomere-support","first","instock","shipping-taxable","purchasable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/decodepeptides.com\/de_at\/wp-json\/wp\/v2\/product\/872","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/decodepeptides.com\/de_at\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/decodepeptides.com\/de_at\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/decodepeptides.com\/de_at\/wp-json\/wp\/v2\/comments?post=872"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/decodepeptides.com\/de_at\/wp-json\/wp\/v2\/media\/2115"}],"wp:attachment":[{"href":"https:\/\/decodepeptides.com\/de_at\/wp-json\/wp\/v2\/media?parent=872"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/decodepeptides.com\/de_at\/wp-json\/wp\/v2\/product_brand?post=872"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/decodepeptides.com\/de_at\/wp-json\/wp\/v2\/product_cat?post=872"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/decodepeptides.com\/de_at\/wp-json\/wp\/v2\/product_tag?post=872"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}