{"id":873,"date":"2026-04-23T23:49:25","date_gmt":"2026-04-23T23:49:25","guid":{"rendered":"https:\/\/decodepeptides.com\/?product=ghk-cu"},"modified":"2026-05-29T01:10:58","modified_gmt":"2026-05-29T01:10:58","slug":"ghk-cu","status":"publish","type":"product","link":"https:\/\/decodepeptides.com\/de_at\/product\/ghk-cu\/","title":{"rendered":"GHK-Cu (Copper Peptide) 100mg"},"content":{"rendered":"

GHK-Cu<\/strong> (Glycine-Histidine-Lysine copper complex) was first isolated from human plasma albumin in 1973 by Pickart and Thaler. Its plasma concentration declines from ~200 ng\/mL at age 20 to under 80 ng\/mL by age 60 \u2014 a decline directly correlated with reduced tissue repair capacity. A landmark 2012 study demonstrated that GHK-Cu modulates the expression of 32% of the human genome<\/strong>, making it one of the most wide-ranging regulatory peptides ever characterised. Research applications span wound healing, skin regeneration, hair growth, pulmonary fibrosis, neural repair, and anti-cancer gene expression.<\/p>\n

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\n
\u226599%<\/span>HPLC Purity<\/span><\/div>\n
100mg<\/span>Per Vial<\/span><\/div>\n
50+<\/span>Years Researched<\/span><\/div>\n
3 aa<\/span>Structure<\/span><\/div>\n<\/div>\n
\"GHK-Cu\"GHK-Cu<\/div>\n

Research Data<\/span><\/p>\n

Research Snapshot \u2014 GHK-Cu (Copper Peptide)<\/h2>\n

Key Mechanisms & Pathways<\/h3>\n
    \n
  • Collagen I, III & VI Synthesis<\/strong>Upregulates COL1A1, COL3A1 and decorin \u2014 structural collagen genes critical for skin, tendon and wound repair.<\/li>\n
  • Genomic Reprogramming<\/strong>Modulates expression of 32% of the human genome via VEGF, HGF and anti-inflammatory cytokine gene activation.<\/li>\n
  • MMP \/ TIMP Balance<\/strong>Simultaneously activates MMPs for remodelling and TIMPs for protection \u2014 balanced ECM turnover, not degradation.<\/li>\n
  • Copper-SOD Activation<\/strong>Delivers Cu\u00b2\u207a to superoxide dismutase and lysyl oxidase, driving antioxidant defence and collagen crosslinking.<\/li>\n
  • VEGF & FGF-2 Induction<\/strong>Stimulates angiogenic and fibroblast growth factors, accelerating wound vascularisation and closure.<\/li>\n
  • Neural Regeneration<\/strong>Promotes axonal outgrowth and BDNF expression; used in CNS injury and neuropathy research models.<\/li>\n<\/ul>\n

    Preclinical & Clinical Research Summary<\/h3>\n\n\n\n\n\n\n\n\n
    Research Area<\/th>\nKey Finding<\/th>\nSource<\/th>\n<\/tr>\n<\/thead>\n
    Skin Regeneration<\/td>\nIncreased skin thickness by 120% and collagen density by 70% in aged skin models.<\/td>\nAbdulghani AA et al., 1998 \u2014 J Dermatol Surg<\/td>\n<\/tr>\n
    Wound Healing<\/td>\nAccelerated healing of chronic leg ulcers; improved wound contraction rates clinically.<\/td>\nLeyden JJ et al., 1990<\/td>\n<\/tr>\n
    Hair Growth<\/td>\nEnlarged follicle size; increased KGF (keratinocyte growth factor) expression in vivo.<\/td>\nUno H et al., 1996<\/td>\n<\/tr>\n
    Lung Protection<\/td>\nAttenuated bleomycin-induced pulmonary fibrosis by reducing TGF-\u03b21 and collagen deposition.<\/td>\nCampbell JD et al., 2019<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
    \n

    References<\/h3>\n
      \n
    1. Pickart L et al. “The human tripeptide GHK-Cu in prevention of oxidative stress and degenerative conditions of aging.” Oxid Med Cell Longev<\/em>, 2012;2012:324832.<\/li>\n
    2. Pickart L, Margolina A. “Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data.” Int J Mol Sci<\/em>, 2018;19(7):1987.<\/li>\n
    3. Gorouhi F, Maibach HI. “Role of topical peptides in preventing or treating aged skin.” Int J Cosmet Sci<\/em>, 2009;31(5):327\u2013345.<\/li>\n
    4. Canapp SO et al. “The effect of topical tripeptide-copper complex on healing of ischemic open wounds.” Vet Surg<\/em>, 2003;32(6):515\u2013523.<\/li>\n<\/ol>\n<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"

      GHK-Cu (Glycyl-L-histidyl-L-lysine copper complex) is a naturally occurring copper-binding tripeptide found in human plasma. It is one of the most extensively studied peptides in regenerative biology, cosmetic dermatology, and wound healing research. Each vial contains 100mg of research-grade GHK-Cu as lyophilized powder.<\/p>","protected":false},"featured_media":2116,"comment_status":"open","ping_status":"closed","template":"","meta":{"inline_featured_image":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0},"product_brand":[],"product_cat":[56,55],"product_tag":[212,209,235,239,237,256,254,255,236,238],"class_list":["post-873","product","type-product","status-publish","has-post-thumbnail","product_cat-anti-aging-longevity","product_cat-recovery-healing","product_tag-angiogenesis","product_tag-anti-inflammatory","product_tag-collagen-synthesis","product_tag-copper-peptide","product_tag-hair-growth","product_tag-hplc-verified","product_tag-lyophilized-powder","product_tag-research-grade","product_tag-skin-health","product_tag-wound-repair","first","instock","shipping-taxable","purchasable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/decodepeptides.com\/de_at\/wp-json\/wp\/v2\/product\/873","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/decodepeptides.com\/de_at\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/decodepeptides.com\/de_at\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/decodepeptides.com\/de_at\/wp-json\/wp\/v2\/comments?post=873"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/decodepeptides.com\/de_at\/wp-json\/wp\/v2\/media\/2116"}],"wp:attachment":[{"href":"https:\/\/decodepeptides.com\/de_at\/wp-json\/wp\/v2\/media?parent=873"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/decodepeptides.com\/de_at\/wp-json\/wp\/v2\/product_brand?post=873"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/decodepeptides.com\/de_at\/wp-json\/wp\/v2\/product_cat?post=873"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/decodepeptides.com\/de_at\/wp-json\/wp\/v2\/product_tag?post=873"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}