{"id":874,"date":"2026-04-23T23:49:26","date_gmt":"2026-04-23T23:49:26","guid":{"rendered":"https:\/\/decodepeptides.com\/?product=hcg-5000iu"},"modified":"2026-05-29T01:10:58","modified_gmt":"2026-05-29T01:10:58","slug":"hcg-5000iu","status":"publish","type":"product","link":"https:\/\/decodepeptides.com\/de_at\/product\/hcg-5000iu\/","title":{"rendered":"HCG (Human Chorionic Gonadotropin) 5000 IU"},"content":{"rendered":"

Human Chorionic Gonadotropin (HCG)<\/strong> is a 237-amino-acid glycoprotein hormone composed of an alpha (92 aa) and beta (145 aa) subunit. It binds the luteinising hormone receptor (LHR) with equal affinity to endogenous LH, making it the standard pharmacological tool for studying Leydig cell steroidogenesis, ovarian function, HPG axis regulation, and reproductive endocrinology. HCG has been in clinical use since the 1950s and has one of the longest and most extensively documented safety and efficacy profiles of any peptide hormone in medicine.<\/p>\n

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\n
\u226598%<\/span>HPLC Purity<\/span><\/div>\n
5000 IU<\/span>Per Vial<\/span><\/div>\n
60+<\/span>Years Researched<\/span><\/div>\n
237 aa<\/span>Structure<\/span><\/div>\n<\/div>\n
\"HCG\"HCG<\/div>\n

Research Data<\/span><\/p>\n

Research Snapshot \u2014 HCG<\/h2>\n

Key Mechanisms & Pathways<\/h3>\n
    \n
  • LH Receptor Agonism<\/strong>Binds and activates the luteinising hormone receptor (LHR) with equal potency to endogenous LH.<\/li>\n
  • Leydig Cell Stimulation<\/strong>Drives testicular testosterone synthesis via cAMP\/PKA\/StAR pathway \u2014 the primary steroidogenic cascade.<\/li>\n
  • Granulosa Cell Activation<\/strong>In females, triggers follicular maturation and ovulation via LHR on granulosa and theca cells.<\/li>\n
  • HPG Axis Research<\/strong>The gold-standard tool for studying the hypothalamo-pituitary-gonadal axis in male and female models.<\/li>\n
  • Cryptorchidism Models<\/strong>Used to evaluate testicular descent and Leydig cell function in neonatal animal models.<\/li>\n
  • Pregnancy \/ Implantation<\/strong>Maintains corpus luteum progesterone production during early pregnancy; used in IVF support research.<\/li>\n<\/ul>\n

    Preclinical & Clinical Research Summary<\/h3>\n\n\n\n\n\n\n\n\n
    Research Area<\/th>\nKey Finding<\/th>\nSource<\/th>\n<\/tr>\n<\/thead>\n
    Testosterone Synthesis<\/td>\nStimulates Leydig cell testosterone production via LHR\/cAMP\/StAR pathway.<\/td>\nHuhtaniemi I, 2018 \u2014 Best Pract Res Clin Endocrinol Metab<\/td>\n<\/tr>\n
    Ovulation Induction<\/td>\nTriggers follicular rupture in ART protocols; primary ovulation trigger in IVF.<\/td>\nBosch E et al., 2020 \u2014 Hum Reprod Update<\/td>\n<\/tr>\n
    Hypogonadism Research<\/td>\nRestores testicular volume and testosterone in secondary hypogonadism models.<\/td>\nRaivio T et al., 2007 \u2014 N Engl J Med<\/td>\n<\/tr>\n
    Placental Biology<\/td>\nMaintains CL progesterone production; essential model for implantation research.<\/td>\nStenman UH et al., 2008<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
    \n

    References<\/h3>\n
      \n
    1. Huhtaniemi I. “A short evolutionary history of FSH-stimulated spermatogenesis.” Hormones (Athens)<\/em>, 2015;14(4):468\u2013478.<\/li>\n
    2. Bosch E et al. “ESHRE guideline: ovarian stimulation for IVF\/ICSI.” Hum Reprod Open<\/em>, 2020;2020(2):hoaa009.<\/li>\n
    3. Raivio T et al. “Reversal of idiopathic hypogonadotropic hypogonadism.” N Engl J Med<\/em>, 2007;357(9):863\u2013873.<\/li>\n
    4. Stenman UH et al. “The clinical significance of human chorionic gonadotropin.” Ann Med<\/em>, 2004;36(1):5\u201314.<\/li>\n<\/ol>\n<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"

      HCG (Human Chorionic Gonadotropin) is a glycoprotein hormone structurally similar to Luteinizing Hormone (LH), sharing the same LH receptor. It is produced naturally during pregnancy and plays a central role in reproductive biology research. This research-grade vial contains 5000 IU of lyophilized HCG.<\/p>","protected":false},"featured_media":2118,"comment_status":"open","ping_status":"closed","template":"","meta":{"inline_featured_image":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0},"product_brand":[],"product_cat":[58],"product_tag":[241,242,244,256,257,243,254,255,240],"class_list":["post-874","product","type-product","status-publish","has-post-thumbnail","product_cat-hormones-reproductive-health","product_tag-fertility","product_tag-hcg","product_tag-hormone-balance","product_tag-hplc-verified","product_tag-injectable-peptide","product_tag-lh-fsh","product_tag-lyophilized-powder","product_tag-research-grade","product_tag-testosterone","first","instock","shipping-taxable","purchasable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/decodepeptides.com\/de_at\/wp-json\/wp\/v2\/product\/874","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/decodepeptides.com\/de_at\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/decodepeptides.com\/de_at\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/decodepeptides.com\/de_at\/wp-json\/wp\/v2\/comments?post=874"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/decodepeptides.com\/de_at\/wp-json\/wp\/v2\/media\/2118"}],"wp:attachment":[{"href":"https:\/\/decodepeptides.com\/de_at\/wp-json\/wp\/v2\/media?parent=874"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/decodepeptides.com\/de_at\/wp-json\/wp\/v2\/product_brand?post=874"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/decodepeptides.com\/de_at\/wp-json\/wp\/v2\/product_cat?post=874"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/decodepeptides.com\/de_at\/wp-json\/wp\/v2\/product_tag?post=874"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}