{"id":876,"date":"2026-04-23T23:49:28","date_gmt":"2026-04-23T23:49:28","guid":{"rendered":"https:\/\/decodepeptides.com\/?product=igf-1-lr3-1mg"},"modified":"2026-05-29T01:10:58","modified_gmt":"2026-05-29T01:10:58","slug":"igf-1-lr3-1mg","status":"publish","type":"product","link":"https:\/\/decodepeptides.com\/de_at\/product\/igf-1-lr3-1mg\/","title":{"rendered":"IGF-1 LR3 1mg"},"content":{"rendered":"

IGF-1 LR3<\/strong> (Insulin-like Growth Factor-1 Long R3) is a recombinant analogue of endogenous IGF-1 with an N-terminal methionine extension and a glutamic acid\u2192arginine substitution at position 3. This R3 modification reduces binding affinity to IGF-binding proteins (IGFBP-1 through -6) by over 1000-fold, extending the plasma half-life from ~12 minutes to 20\u201330 hours<\/strong> and dramatically increasing bioavailability at peripheral tissue receptors. It is the preferred research tool for studying mTOR-driven protein synthesis, muscle satellite cell biology, anti-catabolic mechanisms, and neurotrophy \u2014 independently of hepatic IGFBP sequestration.<\/p>\n

\n
\n
\u226599%<\/span>HPLC Purity<\/span><\/div>\n
1mg<\/span>Per Vial<\/span><\/div>\n
30+<\/span>Years Researched<\/span><\/div>\n
83 aa<\/span>Structure<\/span><\/div>\n<\/div>\n
\"IGF-1\"IGF-1<\/div>\n

Research Data<\/span><\/p>\n

Research Snapshot \u2014 IGF-1 LR3<\/h2>\n

Key Mechanisms & Pathways<\/h3>\n
    \n
  • PI3K \u2192 Akt \u2192 mTORC1<\/strong>Phosphorylates S6K1 and 4E-BP1 \u2014 the two rate-limiting steps in ribosomal biogenesis and protein translation initiation.<\/li>\n
  • Ras \u2192 MEK \u2192 ERK<\/strong>Drives G1\u2192S cell cycle progression via cyclin D1; regulates DNA replication and myoblast differentiation.<\/li>\n
  • FOXO Suppression<\/strong>Akt phosphorylates FOXO1\/3a, preventing transcription of atrophy genes MuRF1 and Atrogin-1 \u2014 blocking muscle proteolysis.<\/li>\n
  • Satellite Cell Activation<\/strong>IGF-1R on muscle stem cells drives proliferation and differentiation into new myofibres \u2014 adding myonuclei.<\/li>\n
  • IGFBP-3 Bypass<\/strong>R3 substitution reduces IGFBP binding affinity by >1000\u00d7, extending half-life from 12 min to 20\u201330 hours.<\/li>\n
  • Neurotrophy<\/strong>Promotes neuron survival, axonal regeneration and oligodendrocyte differentiation in CNS injury models.<\/li>\n<\/ul>\n

    Preclinical & Clinical Research Summary<\/h3>\n\n\n\n\n\n\n\n\n
    Research Area<\/th>\nKey Finding<\/th>\nSource<\/th>\n<\/tr>\n<\/thead>\n
    Muscle Hypertrophy<\/td>\n+25% muscle mass in 7 days via local injection in rat hindlimb \u2014 without systemic GH.<\/td>\nColeman ME et al., 1995 \u2014 J Biol Chem<\/td>\n<\/tr>\n
    Satellite Cell Activation<\/td>\n3.5\u00d7 satellite cell proliferation vs. native IGF-1 at equal molar doses in human myoblasts.<\/td>\nFoulstone EJ et al., 2003 \u2014 J Cell Physiol<\/td>\n<\/tr>\n
    Anti-Catabolism<\/td>\nSignificantly attenuated muscle protein catabolism and nitrogen loss in burn injury models.<\/td>\nHerndon DN et al., 1999 \u2014 Ann Surg<\/td>\n<\/tr>\n
    Neuronal Survival<\/td>\nNeurotrophic \u2014 extended half-life optimal for ALS, neuropathy and axonal regeneration models.<\/td>\nIshii DN et al., 1994<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
    \n

    References<\/h3>\n
      \n
    1. Coleman ME et al. “Myogenic vector expression of insulin-like growth factor I stimulates muscle cell differentiation and myofiber hypertrophy.” J Biol Chem<\/em>, 1995;270(20):12109\u201312116.<\/li>\n
    2. LeRoith D et al. “The role of the insulin-like growth factor-I receptor in cancer.” Ann N Y Acad Sci<\/em>, 2003;995:58\u201368.<\/li>\n
    3. Foulstone EJ et al. “Role of insulin-like growth factor binding protein-3 in the insulin-like growth factor axis of human skeletal muscle.” J Cell Physiol<\/em>, 2003;196(2):229\u2013240.<\/li>\n
    4. Singleton JR et al. “Insulin-like growth factor I signaling in motor neuron disease.” Brain Res<\/em>, 2000;888(2):241\u2013248.<\/li>\n<\/ol>\n<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"

      IGF-1 LR3 (Insulin-like Growth Factor-1 Long R3) is a synthetic analog of endogenous IGF-1, engineered with an 83 amino acid sequence that includes a 13 amino acid N-terminal extension and an arginine substitution at position 3. These modifications significantly extend its half-life and potency compared to native IGF-1. Each vial contains 1mg of research-grade IGF-1 LR3.<\/p>","protected":false},"featured_media":2119,"comment_status":"open","ping_status":"closed","template":"","meta":{"inline_featured_image":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0},"product_brand":[],"product_cat":[57],"product_tag":[212,233,234,256,231,222,254,232,255,206],"class_list":["post-876","product","type-product","status-publish","has-post-thumbnail","product_cat-growth-performance","product_tag-angiogenesis","product_tag-bone-density","product_tag-gh-axis","product_tag-hplc-verified","product_tag-igf-1","product_tag-insulin-sensitivity","product_tag-lyophilized-powder","product_tag-muscle-growth","product_tag-research-grade","product_tag-tissue-repair","first","instock","shipping-taxable","purchasable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/decodepeptides.com\/de_at\/wp-json\/wp\/v2\/product\/876","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/decodepeptides.com\/de_at\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/decodepeptides.com\/de_at\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/decodepeptides.com\/de_at\/wp-json\/wp\/v2\/comments?post=876"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/decodepeptides.com\/de_at\/wp-json\/wp\/v2\/media\/2119"}],"wp:attachment":[{"href":"https:\/\/decodepeptides.com\/de_at\/wp-json\/wp\/v2\/media?parent=876"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/decodepeptides.com\/de_at\/wp-json\/wp\/v2\/product_brand?post=876"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/decodepeptides.com\/de_at\/wp-json\/wp\/v2\/product_cat?post=876"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/decodepeptides.com\/de_at\/wp-json\/wp\/v2\/product_tag?post=876"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}