{"id":880,"date":"2026-04-23T23:49:32","date_gmt":"2026-04-23T23:49:32","guid":{"rendered":"https:\/\/decodepeptides.com\/?product=pt-141-bremelanotide"},"modified":"2026-05-29T01:10:58","modified_gmt":"2026-05-29T01:10:58","slug":"pt-141-bremelanotide","status":"publish","type":"product","link":"https:\/\/decodepeptides.com\/de_at\/product\/pt-141-bremelanotide\/","title":{"rendered":"PT-141 (Bremelanotide) 10mg"},"content":{"rendered":"

PT-141<\/strong> (bremelanotide) is a synthetic cyclic heptapeptide analogue of alpha-MSH, and the active metabolite of Melanotan II. In 2019 it became the world’s first FDA-approved drug for hypoactive sexual desire disorder (HSDD) in premenopausal women (Vyleesi\u2122), and the only approved sexual dysfunction therapy to act purely within the central nervous system \u2014 via melanocortin receptors (MC3R\/MC4R) in the hypothalamus \u2014 rather than peripherally via vascular mechanisms like PDE5 inhibitors. This makes it the primary research tool for studying CNS arousal circuits, melanocortin-dopamine cross-talk, and sexual dysfunction neuropharmacology.<\/p>\n

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\u226599%<\/span>HPLC Purity<\/span><\/div>\n
10mg<\/span>Per Vial<\/span><\/div>\n
25+<\/span>Years Researched<\/span><\/div>\n
7 aa<\/span>Structure<\/span><\/div>\n<\/div>\n
\"PT-141\"PT-141<\/div>\n

Research Data<\/span><\/p>\n

Research Snapshot \u2014 PT-141<\/h2>\n

Key Mechanisms & Pathways<\/h3>\n
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  • MC4R Agonism \/ PVN<\/strong>Activates melanocortin-4 receptor in the paraventricular nucleus \u2014 triggering dopamine release in the NAc and initiating the central arousal cascade.<\/li>\n
  • MC3R Agonism \/ ARC<\/strong>MC3R activation in arcuate nucleus initiates sexual motivation circuits and modulates energy homeostasis cross-talk.<\/li>\n
  • Mesolimbic Dopamine<\/strong>D1\/D2 receptor-mediated dopamine signalling in the MPOA \u2014 the brain region essential for sexual motivation in all mammals.<\/li>\n
  • Spinal Erection Centres<\/strong>MC4R in thoracolumbar intermediolateral columns activates pro-erectile spinal circuits \u2014 effective even in PDE5 non-responders.<\/li>\n
  • Endogenous OTR Release<\/strong>MC4R activation in PVN directly stimulates oxytocin release from parvocellular neurons \u2014 linking melanocortin and OTR systems.<\/li>\n
  • Serotonin 5-HT2C Cross-Talk<\/strong>Reduces inhibitory serotonergic tone on sexual motivation pathways \u2014 complementing dopaminergic arousal circuits.<\/li>\n<\/ul>\n

    Preclinical & Clinical Research Summary<\/h3>\n\n\n\n\n\n\n\n\n
    Research Area<\/th>\nKey Finding<\/th>\nSource<\/th>\n<\/tr>\n<\/thead>\n
    FDA Approval (HSDD)<\/td>\nBremelanotide (Vyleesi) approved June 2019 for premenopausal HSDD \u2014 first CNS-acting sexual dysfunction drug.<\/td>\nFDA approval 2019<\/td>\n<\/tr>\n
    Phase III Efficacy<\/td>\nRECONNECT trials: significant increase in SSEs and reduced FSDS-DAO distress scores; p<0.001 for both endpoints.<\/td>\nKingsberg SA et al., 2019 \u2014 Obstet Gynecol<\/td>\n<\/tr>\n
    PDE5 Non-Responders<\/td>\nProduced erections in 17\/20 men who had completely failed sildenafil \u2014 including severe vascular disease cases.<\/td>\nShadiack AM et al., 2007 \u2014 Ann NY Acad Sci<\/td>\n<\/tr>\n
    Genital Arousal<\/td>\nIncreased vaginal pulse amplitude (objective haemodynamic measure) in both sexually dysfunctional and healthy women.<\/td>\nPfaus JG et al., 2004<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
    \n

    References<\/h3>\n
      \n
    1. Kingsberg SA et al. “Bremelanotide for the Treatment of Hypoactive Sexual Desire Disorder.” Obstet Gynecol<\/em>, 2019;134(5):899\u2013908.<\/li>\n
    2. Simon JA et al. “Bremelanotide: pharmacology and clinical efficacy in female sexual dysfunction.” Clin Obstet Gynecol<\/em>, 2019;62(4):732\u2013743.<\/li>\n
    3. Shadiack AM et al. “Melanocortins in the treatment of male and female sexual dysfunction.” Curr Top Med Chem<\/em>, 2007;7(11):1137\u20131144.<\/li>\n
    4. Pfaus JG et al. “Who, what, where, when (and maybe even why)? How sexual reward connects desire, preference, and performance.” Arch Sex Behav<\/em>, 2012;41(1):31\u201362.<\/li>\n<\/ol>\n<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"

      PT-141 (Bremelanotide) is a synthetic cyclic heptapeptide analog of alpha-melanocyte-stimulating hormone (a-MSH), acting as a melanocortin receptor agonist. Unlike PDE5 inhibitors (Viagra, Cialis), PT-141 works via the central nervous system by activating melanocortin receptors in the hypothalamus. It is the first peptide approved for female sexual dysfunction. Each vial contains 10mg of research-grade PT-141.<\/p>","protected":false},"featured_media":2123,"comment_status":"open","ping_status":"closed","template":"","meta":{"inline_featured_image":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0},"product_brand":[],"product_cat":[58],"product_tag":[248,249,256,245,254,247,211,255,246],"class_list":["post-880","product","type-product","status-publish","has-post-thumbnail","product_cat-hormones-reproductive-health","product_tag-erectile-function","product_tag-female-arousal","product_tag-hplc-verified","product_tag-libido","product_tag-lyophilized-powder","product_tag-melanocortin","product_tag-neuroprotection","product_tag-research-grade","product_tag-sexual-function","first","instock","shipping-taxable","purchasable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/decodepeptides.com\/de_at\/wp-json\/wp\/v2\/product\/880","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/decodepeptides.com\/de_at\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/decodepeptides.com\/de_at\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/decodepeptides.com\/de_at\/wp-json\/wp\/v2\/comments?post=880"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/decodepeptides.com\/de_at\/wp-json\/wp\/v2\/media\/2123"}],"wp:attachment":[{"href":"https:\/\/decodepeptides.com\/de_at\/wp-json\/wp\/v2\/media?parent=880"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/decodepeptides.com\/de_at\/wp-json\/wp\/v2\/product_brand?post=880"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/decodepeptides.com\/de_at\/wp-json\/wp\/v2\/product_cat?post=880"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/decodepeptides.com\/de_at\/wp-json\/wp\/v2\/product_tag?post=880"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}