{"id":875,"date":"2026-04-23T23:49:27","date_gmt":"2026-04-23T23:49:27","guid":{"rendered":"https:\/\/decodepeptides.com\/?product=hgh-somatropin-100iu"},"modified":"2026-05-29T01:10:58","modified_gmt":"2026-05-29T01:10:58","slug":"hgh-somatropin-100iu","status":"publish","type":"product","link":"https:\/\/decodepeptides.com\/nl_nl\/product\/hgh-somatropin-100iu\/","title":{"rendered":"HGH Somatropin 100 IU"},"content":{"rendered":"

HGH Somatropin<\/strong> is the 191-amino-acid recombinant human growth hormone, structurally identical to pituitary-derived GH. FDA-approved since 1985, it acts via the GH receptor (GHR) to activate JAK2\/STAT5b \u2014 driving hepatic IGF-1 production \u2014 as well as MAPK\/ERK and PI3K\/Akt pathways. Clinically and preclinically, it is the most studied peptide hormone for body composition, bone biology, wound healing, and metabolic regulation. The landmark 1990 Rudman study in the New England Journal of Medicine established HGH as the benchmark for anti-aging research protocols.<\/p>\n

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\n
\u226599%<\/span>HPLC Purity<\/span><\/div>\n
100 IU<\/span>Per Vial<\/span><\/div>\n
40+<\/span>Years Researched<\/span><\/div>\n
191 aa<\/span>Structure<\/span><\/div>\n<\/div>\n
\"HGH\"HGH<\/div>\n

Research Data<\/span><\/p>\n

Research Snapshot \u2014 HGH Somatropin<\/h2>\n

Key Mechanisms & Pathways<\/h3>\n
    \n
  • JAK2 \/ STAT5b Pathway<\/strong>Primary GHR signalling cascade; drives IGF-1 transcription in hepatocytes \u2014 the key anabolic mediator.<\/li>\n
  • MAPK \/ ERK Pathway<\/strong>Regulates cell proliferation and differentiation; mediates anti-apoptotic effects in muscle and liver.<\/li>\n
  • PI3K \/ Akt \/ mTOR<\/strong>Promotes protein synthesis, glucose uptake and cell survival via the canonical anabolic kinase cascade.<\/li>\n
  • Direct Lipolysis<\/strong>Activates hormone-sensitive lipase (HSL) in adipocytes, shifting energy substrate toward fatty acid oxidation.<\/li>\n
  • IGF-1 \/ IGFBP-3 Induction<\/strong>Drives hepatic production of IGF-1 and its binding protein \u2014 the primary downstream anabolic effectors.<\/li>\n
  • Osteoblast Stimulation<\/strong>Via IGF-1, drives bone matrix synthesis and mineralisation \u2014 the mechanism behind GH-driven BMD increases.<\/li>\n<\/ul>\n

    Preclinical & Clinical Research Summary<\/h3>\n\n\n\n\n\n\n\n\n
    Research Area<\/th>\nKey Finding<\/th>\nSource<\/th>\n<\/tr>\n<\/thead>\n
    Body Composition<\/td>\n+5\u201310% lean mass, \u221210\u201320% fat mass after 6 months in GH-deficient adults.<\/td>\nJorgensen JO et al., 1989 \u2014 Lancet<\/td>\n<\/tr>\n
    Bone Density<\/td>\n+4\u20138% BMD per year in GH-deficient adults via IGF-1-driven osteoblast stimulation.<\/td>\nRosen T et al., 1997 \u2014 J Clin Endocrinol Metab<\/td>\n<\/tr>\n
    Wound Healing<\/td>\nIncreased collagen synthesis by 50\u2013100%; accelerated burn wound healing clinically.<\/td>\nHerndon DN et al., 1990 \u2014 Ann Surg<\/td>\n<\/tr>\n
    Age Reversal Markers<\/td>\nRudman study: +8.8% lean mass, +1.6% BMD, +7.1% skin thickness in men over 60.<\/td>\nRudman D et al., 1990 \u2014 N Engl J Med<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
    \n

    References<\/h3>\n
      \n
    1. Jorgensen JO et al. “Beneficial effects of growth hormone treatment in GH-deficient adults.” Lancet<\/em>, 1989;1(8649):1221\u20131225.<\/li>\n
    2. Rudman D et al. “Effects of human growth hormone in men over 60 years old.” N Engl J Med<\/em>, 1990;323(1):1\u20136.<\/li>\n
    3. Molitch ME et al. “Evaluation and treatment of adult growth hormone deficiency.” J Clin Endocrinol Metab<\/em>, 2011;96(6):1587\u20131609.<\/li>\n
    4. Herndon DN et al. “Muscle protein catabolism after severe burn: effects of IGF-1\/IGFBP-3 treatment.” Ann Surg<\/em>, 1999;229(5):713.<\/li>\n<\/ol>\n<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"

      HGH Somatropin is recombinant human growth hormone (rHGH) produced via recombinant DNA technology, consisting of 191 amino acids \u2014 identical to endogenous pituitary-derived growth hormone. This research-grade product contains 100 IU (10 vials x 10 IU) as lyophilized powder, suitable for in-vitro and preclinical research applications.<\/p>","protected":false},"featured_media":2117,"comment_status":"open","ping_status":"closed","template":"","meta":{"inline_featured_image":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0},"product_brand":[],"product_cat":[57],"product_tag":[213,233,224,234,230,256,231,257,254,232,255],"class_list":["post-875","product","type-product","status-publish","has-post-thumbnail","product_cat-growth-performance","product_tag-anti-aging","product_tag-bone-density","product_tag-fat-oxidation","product_tag-gh-axis","product_tag-growth-hormone","product_tag-hplc-verified","product_tag-igf-1","product_tag-injectable-peptide","product_tag-lyophilized-powder","product_tag-muscle-growth","product_tag-research-grade","first","instock","shipping-taxable","purchasable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/decodepeptides.com\/nl_nl\/wp-json\/wp\/v2\/product\/875","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/decodepeptides.com\/nl_nl\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/decodepeptides.com\/nl_nl\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/decodepeptides.com\/nl_nl\/wp-json\/wp\/v2\/comments?post=875"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/decodepeptides.com\/nl_nl\/wp-json\/wp\/v2\/media\/2117"}],"wp:attachment":[{"href":"https:\/\/decodepeptides.com\/nl_nl\/wp-json\/wp\/v2\/media?parent=875"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/decodepeptides.com\/nl_nl\/wp-json\/wp\/v2\/product_brand?post=875"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/decodepeptides.com\/nl_nl\/wp-json\/wp\/v2\/product_cat?post=875"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/decodepeptides.com\/nl_nl\/wp-json\/wp\/v2\/product_tag?post=875"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}