{"id":877,"date":"2026-04-23T23:49:29","date_gmt":"2026-04-23T23:49:29","guid":{"rendered":"https:\/\/decodepeptides.com\/?product=mots-c"},"modified":"2026-05-29T01:10:58","modified_gmt":"2026-05-29T01:10:58","slug":"mots-c","status":"publish","type":"product","link":"https:\/\/decodepeptides.com\/nl_nl\/product\/mots-c\/","title":{"rendered":"MOTS-C 10mg"},"content":{"rendered":"

MOTS-C<\/strong> is a 16-amino-acid peptide encoded within the mitochondrial 12S rRNA \u2014 a region previously considered non-coding. Discovered in 2015 by Lee et al. at USC, it is a founding member of the mitochondrial-derived peptides (MDPs)<\/strong> \u2014 a new class of retrograde signalling molecules that travel from mitochondria to the nucleus to regulate energy homeostasis. MOTS-C plasma levels decline with age and obesity, making it a key biomarker and research tool for metabolic dysfunction, exercise biology, insulin resistance, and longevity \u2014 with its unique AMPK activation mechanism entirely distinct from any existing pharmacological class.<\/p>\n

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\u226599%<\/span>HPLC Purity<\/span><\/div>\n
10mg<\/span>Per Vial<\/span><\/div>\n
10+<\/span>Years Researched<\/span><\/div>\n
16 aa<\/span>Structure<\/span><\/div>\n<\/div>\n
\"MOTS-C\"MOTS-C<\/div>\n

Research Data<\/span><\/p>\n

Research Snapshot \u2014 MOTS-C<\/h2>\n

Key Mechanisms & Pathways<\/h3>\n
    \n
  • AMPK Activation via AICAR<\/strong>Inhibits MTHFD1 in the folate cycle \u2192 AICAR accumulation \u2192 AMPK phosphorylation at Thr172 \u2014 mimicking aerobic exercise.<\/li>\n
  • Nuclear Retrograde Signal<\/strong>Translocates from mitochondria to nucleus under metabolic stress, directly modifying ARE\/Nrf2 gene expression.<\/li>\n
  • GLUT4 Translocation<\/strong>AMPK-driven TBC1D1\/AS160 phosphorylation drives GLUT4 vesicle fusion \u2014 glucose uptake without insulin receptor activation.<\/li>\n
  • \u03b2-Oxidation Enhancement<\/strong>AMPK inhibits ACC, reducing malonyl-CoA and relieving CPT-1 inhibition \u2192 increased mitochondrial fatty acid import.<\/li>\n
  • mTORC1 Suppression<\/strong>AMPK phosphorylates TSC2 and Raptor, suppressing anabolic mTORC1 \u2014 the signature metabolic state of caloric restriction.<\/li>\n
  • NF-\u03baB Anti-Inflammatory<\/strong>Suppresses IL-6, TNF-\u03b1 and IL-1\u03b2 in inflammatory challenge models; improved survival in sepsis models.<\/li>\n<\/ul>\n

    Preclinical & Clinical Research Summary<\/h3>\n\n\n\n\n\n\n\n\n
    Research Area<\/th>\nKey Finding<\/th>\nSource<\/th>\n<\/tr>\n<\/thead>\n
    Obesity Prevention<\/td>\n\u221235% body weight gain vs. HFD controls; near-normal glucose tolerance restored.<\/td>\nLee C et al., 2015 \u2014 Cell Metab<\/td>\n<\/tr>\n
    Exercise Mimicry<\/td>\nMOTS-C plasma rises during exercise; exogenous admin reproduces key metabolic training adaptations.<\/td>\nReynolds JC et al., 2021 \u2014 Nat Commun<\/td>\n<\/tr>\n
    Insulin Sensitivity<\/td>\nImproved skeletal muscle glucose disposal independently of insulin receptor signalling.<\/td>\nKim KH et al., 2019 \u2014 Exp Mol Med<\/td>\n<\/tr>\n
    Aging \/ Healthspan<\/td>\nRestored physical performance and insulin sensitivity in aged mice; extended healthspan.<\/td>\nLee C et al., 2015 \u2014 Cell Metab<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
    \n

    References<\/h3>\n
      \n
    1. Lee C et al. “The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance.” Cell Metab<\/em>, 2015;21(3):443\u2013454.<\/li>\n
    2. Reynolds JC et al. “MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis.” Nat Commun<\/em>, 2021;12:470.<\/li>\n
    3. Kim KH et al. “MOTS-c peptide increases physical endurance and insulin sensitivity.” Exp Mol Med<\/em>, 2019;51:1\u201312.<\/li>\n
    4. Bhaskaran S et al. “Mitochondria-derived peptide MOTS-c restores cardiovascular function during aging.” Ageing Res Rev<\/em>, 2020;62:101128.<\/li>\n<\/ol>\n<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"

      MOTS-C (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a 16 amino acid mitochondria-derived peptide encoded within the mitochondrial 12S ribosomal RNA gene. It is one of the most recently discovered mitochondrial peptides, studied for its profound effects on metabolic regulation, insulin sensitivity, exercise capacity, and aging. Each vial contains 10mg of research-grade MOTS-C.<\/p>","protected":false},"featured_media":2120,"comment_status":"open","ping_status":"closed","template":"","meta":{"inline_featured_image":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0},"product_brand":[],"product_cat":[56],"product_tag":[229,228,224,256,222,214,254,221,225,255],"class_list":["post-877","product","type-product","status-publish","has-post-thumbnail","product_cat-anti-aging-longevity","product_tag-endurance","product_tag-exercise-mimetic","product_tag-fat-oxidation","product_tag-hplc-verified","product_tag-insulin-sensitivity","product_tag-longevity","product_tag-lyophilized-powder","product_tag-metabolic-health","product_tag-mitochondrial-health","product_tag-research-grade","first","instock","shipping-taxable","purchasable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/decodepeptides.com\/nl_nl\/wp-json\/wp\/v2\/product\/877","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/decodepeptides.com\/nl_nl\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/decodepeptides.com\/nl_nl\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/decodepeptides.com\/nl_nl\/wp-json\/wp\/v2\/comments?post=877"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/decodepeptides.com\/nl_nl\/wp-json\/wp\/v2\/media\/2120"}],"wp:attachment":[{"href":"https:\/\/decodepeptides.com\/nl_nl\/wp-json\/wp\/v2\/media?parent=877"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/decodepeptides.com\/nl_nl\/wp-json\/wp\/v2\/product_brand?post=877"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/decodepeptides.com\/nl_nl\/wp-json\/wp\/v2\/product_cat?post=877"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/decodepeptides.com\/nl_nl\/wp-json\/wp\/v2\/product_tag?post=877"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}