Zusätzliche Informationen
| Pack Size | 1 Vial, 10 Pack, 5 Pack |
|---|
Research Use Only
MOTS-C 10 mg
€ 40
| Quantity | Unit price | Savings |
|---|---|---|
| 1–4 units | € 50 | Base |
| 5–9 units | € 42 | −15% |
| 10+ units | € 40 | −20% |
Worldwide Shipping
Secure Checkout
Vollständiges Echtheitszertifikat enthalten
Ships within 24h
≥99% HPLC Purity
Forschungsqualität
Cold-Chain Shipped
Research Use Only
WÖRTER-C is a 16-amino-acid peptide encoded within the mitochondrial 12S rRNA — a region previously considered non-coding. Discovered in 2015 by Lee et al. at USC, it is a founding member of the mitochondrial-derived peptides (MDPs) — a new class of retrograde signalling molecules that travel from mitochondria to the nucleus to regulate energy homeostasis. MOTS-C plasma levels decline with age and obesity, making it a key biomarker and research tool for metabolic dysfunction, exercise biology, insulin resistance, and longevity — with its unique AMPK activation mechanism entirely distinct from any existing pharmacological class.
≥99%HPLC-Reinheit
10 mgVon Vial
10+Jahre der Recherche
16 aaStruktur
Forschungsdaten
Research Snapshot — MOTS-C
Schlüsselmechanismen und Signalwege
- AMPK Activation via AICARInhibits MTHFD1 in the folate cycle → AICAR accumulation → AMPK phosphorylation at Thr172 — mimicking aerobic exercise.
- Nuclear Retrograde SignalTranslocates from mitochondria to nucleus under metabolic stress, directly modifying ARE/Nrf2 gene expression.
- GLUT4 TranslocationAMPK-driven TBC1D1/AS160 phosphorylation drives GLUT4 vesicle fusion — glucose uptake without insulin receptor activation.
- β-Oxidation EnhancementAMPK inhibits ACC, reducing malonyl-CoA and relieving CPT-1 inhibition → increased mitochondrial fatty acid import.
- mTORC1 SuppressionAMPK phosphorylates TSC2 and Raptor, suppressing anabolic mTORC1 — the signature metabolic state of caloric restriction.
- NF-κB entzündungshemmendSuppresses IL-6, TNF-α and IL-1β in inflammatory challenge models; improved survival in sepsis models.
Zusammenfassung der präklinischen und klinischen Forschung
| Forschungsgebiet | Wichtigste Erkenntnis | Quelle |
|---|---|---|
| Obesity Prevention | −35% body weight gain vs. HFD controls; near-normal glucose tolerance restored. | Lee C et al., 2015 — Cell Metab |
| Exercise Mimicry | MOTS-C plasma rises during exercise; exogenous admin reproduces key metabolic training adaptations. | Reynolds JC et al., 2021 — Nat Commun |
| Insulinempfindlichkeit | Improved skeletal muscle glucose disposal independently of insulin receptor signalling. | Kim KH et al., 2019 — Exp Mol Med |
| Aging / Healthspan | Restored physical performance and insulin sensitivity in aged mice; extended healthspan. | Lee C et al., 2015 — Cell Metab |
Referenzen
- Lee C et al. “The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance.” Cell Metab, 2015;21(3):443–454.
- Reynolds JC et al. “MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis.” Nat Commun, 2021;12:470.
- Kim KH et al. “MOTS-c peptide increases physical endurance and insulin sensitivity.” Exp Mol Med, 2019;51:1–12.
- Bhaskaran S et al. “Mitochondria-derived peptide MOTS-c restores cardiovascular function during aging.” Ageing Res Rev, 2020;62:101128.
Chemical & Physical Details
CAS Number
1627580-64-6
Molecular Formula
C₁₀₁H₁₆₈N₃₄O₃₀
Molecular Weight
2174.7 g/mol
Reinheit
≥99% (HPLC)
Appearance
White lyophilized powder
Solubility
Soluble in sterile water (≥1 mg/mL)
Lagerung
-20 °C (long-term); +4 °C (short-term)
Format
Lyophilisiertes Pulver
Retest Date
2027-03-01
Analysezertifikat
Verify This Batch
Batch DP-2026-MOT-001
| Test | Specification | Result | Method | Status |
|---|---|---|---|---|
| Appearance | White/off-white powder | White lyophilized powder | Visual | PASS |
| Identity (MS) | Conforms to reference | Confirmed | LC-MS/MS | PASS |
| Purity (HPLC) | ≥99.0% | 99.3% | RP-HPLC | PASS |
| Assay (Content) | 95.0–105.0% | 98.8% | HPLC | PASS |
| Bacterial Endotoxins | <5.0 EU/mg | <1.0 EU/mg | LAL | PASS |
| Heavy Metals | <20 ppm | <11 ppm | ICP-MS | PASS |
| Residual Solvents | ICH Q3C limits | Not Detected | GC-HS | PASS |
| Moisture (LOD) | ≤6.0% | 3.1% | Karl Fischer | PASS |
PASS — Released for research use
This Certificate of Analysis is provided for research transparency purposes only. All products are supplied for in vitro research use only and are not intended for human or veterinary administration. Verify batch DP-2026-MOT-001 online →
8 Rezensionen für MOTS-C 10mg
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Research Use Only — Important Notice
For in vitro research use only. Not for human or veterinary use. Not intended to diagnose, treat, cure, or prevent any disease or condition. This product is supplied exclusively for qualified in vitro research. Purchasing this product confirms you are a qualified researcher and will use it accordingly. Learn about our quality standards →
For in vitro research use only. Not for human or veterinary use. Not intended to diagnose, treat, cure, or prevent any disease or condition. This product is supplied exclusively for qualified in vitro research. Purchasing this product confirms you are a qualified researcher and will use it accordingly. Learn about our quality standards →
Peptid-Enzyklopädie – 28 Verbindungen
Alle anzeigen →
🛡️
ARA-290
Immun
🩹
BPC-157
Heilung und Genesung
🧠
Cerebrolysin
Kognitiv
📈
CJC-1295
Wachstumshormon
🧠
Dihexa
Kognitiv
🌙
DSIP (Delta-Schlaf-induzierendes Peptid)
Schlafen
🧬
Epithalon (Epithalon)
Anti-Aging & Langlebigkeit
🩹
GHK-Cu (Kupferpeptid)
Heilung und Genesung
🛡️
HCG (Humanes Choriongonadotropin)
Hormone
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HGH Somatropin
Wachstumshormon
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IGF-1 LR3
Wachstumshormon
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Ipamorelin
Wachstumshormon
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Kisspeptin-10
Hormone
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LL-37 (Cathelicidin)
Immun
💊
Melanotan II
Sexuelle Gesundheit
⚖️
WÖRTER-C
Stoffwechsel
🧬
NAD+ (Nicotinamidadenindinukleotid)
Anti-Aging & Langlebigkeit
💊
Oxytocin
Sexuelle Gesundheit
💊
PT-141 (Bremelanotid)
Sexuelle Gesundheit
⚖️
Retatrutid (LY3437943)
Stoffwechsel
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Selank
Kognitiv
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Semaglutid
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Semax
Kognitiv
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SS-31 (Elamipretid)
Anti-Aging & Langlebigkeit
🩹
TB500 (Thymosin Beta-4)
Heilung und Genesung
🛡️
Thymosin Alpha-1 (Tα1)
Immun
⚖️
Tirzepatide
Stoffwechsel
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VIP (Vasoaktives intestinales Peptid)
Immun
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Nederlands
MOTS-C 10mg is doing the job for my research purposes. metabolic flexibility is the primary outcome I’m tracking and it’s moving in the right direction.
Verifizierter Kauf – Finnland
Impressed by the professionalism. MOTS-C 10mg came with a full COA, proper cold packaging, and exercise recovery results are measurable.
Verifizierter Kauf – Finnland
Best vendor I have tried for MOTS-C 10mg. Purity is clearly above average and exercise recovery results prove it over a 8 week run. Verified purchase from Finland.
Best vendor I have tried for MOTS-C 10mg. Purity is clearly above average and exercise recovery results prove it over a 8 week run. Verified purchase from Finland.
Impressed by the professionalism. MOTS-C 10mg came with a full COA, proper cold packaging, and metabolic flexibility results are measurable.
Verifizierter Kauf – Deutschland
MOTS-C 10mg exceeded my expectations. Noticed exercise recovery improvements within the first two weeks. Reordering immediately.
Verifizierter Kauf – Neuseeland
Third order of MOTS-C 10mg and consistent quality every time. exercise recovery is the main reason I keep coming back.
Verifizierter Kauf – Südkorea
Happy with my MOTS-C 10mg purchase. Shipping was fast and metabolic flexibility protocol is going well. Minor delay on tracking updates but product is great.
Verifizierter Kauf – Irland
Solid product overall. MOTS-C 10mg delivered on mitochondrial efficiency within about 4-5 weeks. Packaging could be slightly better but quality is fine.
Verifizierter Kauf – Norwegen
Very good quality MOTS-C 10mg. insulin sensitivity has been the main focus of my research and results are promising after 8 weeks. Verified purchase from Netherlands.
Very good quality MOTS-C 10mg. insulin sensitivity has been the main focus of my research and results are promising after 8 weeks. Verified purchase from Netherlands.
Average experience with MOTS-C 10mg. exercise recovery showed some improvement but nothing dramatic in my 4 week window so far. Verified purchase from France.
Average experience with MOTS-C 10mg. exercise recovery showed some improvement but nothing dramatic in my 4 week window so far. Verified purchase from France.
Average experience with MOTS-C 10mg. metabolic flexibility showed some improvement but nothing dramatic in my 4 week window so far. Verified purchase from Belgium.
Average experience with MOTS-C 10mg. metabolic flexibility showed some improvement but nothing dramatic in my 4 week window so far. Verified purchase from Belgium.
Solid product overall. MOTS-C 10mg delivered on insulin sensitivity within about 4-5 weeks. Packaging could be slightly more insulated. Verified purchase from Ireland.
Solid product overall. MOTS-C 10mg delivered on insulin sensitivity within about 4-5 weeks. Packaging could be slightly more insulated. Verified purchase from Ireland.
Product quality seems fine but MOTS-C 10mg took longer than expected to show mitochondrial efficiency results. Will continue the protocol. Verified purchase from United Kingdom.
Product quality seems fine but MOTS-C 10mg took longer than expected to show mitochondrial efficiency results. Will continue the protocol. Verified purchase from United Kingdom.
Solid product overall. MOTS-C 10mg delivered on insulin sensitivity within about 4-5 weeks. Packaging could be slightly better but quality is fine.
Verifizierter Kauf – Kanada
Incredible results with MOTS-C 10mg. After 6 weeks I noticed significant improvement in exercise recovery. Will definitely reorder. Verified purchase from Germany.
Incredible results with MOTS-C 10mg. After 6 weeks I noticed significant improvement in exercise recovery. Will definitely reorder. Verified purchase from Germany.
Product quality seems fine but MOTS-C 10mg took longer than expected to show exercise recovery results. Will continue for another month.
Verifizierter Kauf – Neuseeland
Happy with my MOTS-C 10mg purchase. Shipping was fast and exercise recovery protocol is going well. Minor delay on tracking updates but product is great.
Verifizierter Kauf – Finnland
My go-to source for MOTS-C 10mg. The mitochondrial efficiency improvements are consistent across batches which tells me QC is taken seriously. Verified purchase from Czech Republic.
My go-to source for MOTS-C 10mg. The mitochondrial efficiency improvements are consistent across batches which tells me QC is taken seriously. Verified purchase from Czech Republic.