Description
IGF-1 LR3 (Insulin-like Growth Factor-1 Long R3) is a recombinant analogue of endogenous IGF-1 with an N-terminal methionine extension and a glutamic acid→arginine substitution at position 3. This R3 modification reduces binding affinity to IGF-binding proteins (IGFBP-1 through -6) by over 1000-fold, extending the plasma half-life from ~12 minutes to 20–30 hours and dramatically increasing bioavailability at peripheral tissue receptors. It is the preferred research tool for studying mTOR-driven protein synthesis, muscle satellite cell biology, anti-catabolic mechanisms, and neurotrophy — independently of hepatic IGFBP sequestration.
≥99%HPLC Purity
1mgPer Vial
30+Years Researched
83 aaStructure
Research Data
Research Snapshot — IGF-1 LR3
Key Mechanisms & Pathways
- PI3K → Akt → mTORC1Phosphorylates S6K1 and 4E-BP1 — the two rate-limiting steps in ribosomal biogenesis and protein translation initiation.
- Ras → MEK → ERKDrives G1→S cell cycle progression via cyclin D1; regulates DNA replication and myoblast differentiation.
- FOXO SuppressionAkt phosphorylates FOXO1/3a, preventing transcription of atrophy genes MuRF1 and Atrogin-1 — blocking muscle proteolysis.
- Satellite Cell ActivationIGF-1R on muscle stem cells drives proliferation and differentiation into new myofibres — adding myonuclei.
- IGFBP-3 BypassR3 substitution reduces IGFBP binding affinity by >1000×, extending half-life from 12 min to 20–30 hours.
- NeurotrophyPromotes neuron survival, axonal regeneration and oligodendrocyte differentiation in CNS injury models.
Preclinical & Clinical Research Summary
| Research Area | Key Finding | Source |
|---|---|---|
| Muscle Hypertrophy | +25% muscle mass in 7 days via local injection in rat hindlimb — without systemic GH. | Coleman ME et al., 1995 — J Biol Chem |
| Satellite Cell Activation | 3.5× satellite cell proliferation vs. native IGF-1 at equal molar doses in human myoblasts. | Foulstone EJ et al., 2003 — J Cell Physiol |
| Anti-Catabolism | Significantly attenuated muscle protein catabolism and nitrogen loss in burn injury models. | Herndon DN et al., 1999 — Ann Surg |
| Neuronal Survival | Neurotrophic — extended half-life optimal for ALS, neuropathy and axonal regeneration models. | Ishii DN et al., 1994 |
References
- Coleman ME et al. “Myogenic vector expression of insulin-like growth factor I stimulates muscle cell differentiation and myofiber hypertrophy.” J Biol Chem, 1995;270(20):12109–12116.
- LeRoith D et al. “The role of the insulin-like growth factor-I receptor in cancer.” Ann N Y Acad Sci, 2003;995:58–68.
- Foulstone EJ et al. “Role of insulin-like growth factor binding protein-3 in the insulin-like growth factor axis of human skeletal muscle.” J Cell Physiol, 2003;196(2):229–240.
- Singleton JR et al. “Insulin-like growth factor I signaling in motor neuron disease.” Brain Res, 2000;888(2):241–248.
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Decent product. IGF-1 LR3 1mg appears legitimate based on muscle protein synthesis effects but nothing standout compared to my previous source.
Verified purchase — Singapore
Average experience with IGF-1 LR3 1mg. muscle protein synthesis showed some improvement but nothing dramatic in my 4 week window so far. Verified purchase from Singapore.
Average experience with IGF-1 LR3 1mg. muscle protein synthesis showed some improvement but nothing dramatic in my 4 week window so far. Verified purchase from Singapore.
Incredible results with IGF-1 LR3 1mg. After 6 weeks I noticed significant improvements in cell proliferation. Will definitely reorder.
Verified purchase — Sweden
Product quality seems fine but IGF-1 LR3 1mg took longer than expected to show recovery speed results. Will continue for another month.
Verified purchase — France
Been using IGF-1 LR3 1mg for 3 months now. The quality is clearly top-tier — muscle protein synthesis has been noticeably better. Fast shipping too.
Verified purchase — Belgium
Outstanding vendor. Follistatin 344 purity is verifiable, shipping was 2 days, and the myostatin inhibition effects are undeniable at week 4.
Verified purchase — France
Couldn’t be happier. IGF-1 LR3 1mg is consistently dosed and the anabolic signaling effects are exactly what the literature suggests.
Verified purchase — Austria
I’ve tried several vendors for IGF-1 LR3 1mg — Decode is by far the most reliable. Purity is what you pay for and it shows.
Verified purchase — Sweden
Outstanding vendor. IGF-1 LR3 1mg purity is verifiable, shipping was 2 days, and recovery speed effects are undeniable at week 4. Verified purchase from Finland.
Outstanding vendor. IGF-1 LR3 1mg purity is verifiable, shipping was 2 days, and recovery speed effects are undeniable at week 4. Verified purchase from Finland.
Best vendor I have tried for Follistatin 344. Purity is clearly above average and lean mass results prove it over a 8 week run. Verified purchase from Denmark.
Best vendor I have tried for Follistatin 344. Purity is clearly above average and lean mass results prove it over a 8 week run. Verified purchase from Denmark.
Very good quality Follistatin 344. muscle hypertrophy has been the main focus of my research and results are promising after 8 weeks. Verified purchase from Ireland.
Very good quality Follistatin 344. muscle hypertrophy has been the main focus of my research and results are promising after 8 weeks. Verified purchase from Ireland.
Good experience with IGF-1 LR3 1mg. anabolic signaling improvements are noticeable though took a bit longer than expected. Quality seems solid.
Verified purchase — Germany
As a researcher, I am very particular about purity. The COA for IGF-1 LR3 1mg confirmed 99.2 percent purity. Outstanding. Verified purchase from Sweden.
As a researcher, I am very particular about purity. The COA for IGF-1 LR3 1mg confirmed 99.2 percent purity. Outstanding. Verified purchase from Sweden.
Research grade as advertised. Follistatin 344 is exactly what I needed for lean mass research. COA provided without asking. Verified purchase from Austria.
Research grade as advertised. Follistatin 344 is exactly what I needed for lean mass research. COA provided without asking. Verified purchase from Austria.
Product quality seems fine but IGF-1 LR3 1mg took longer than expected to show nitrogen retention results. Will continue the protocol. Verified purchase from Austria.
Product quality seems fine but IGF-1 LR3 1mg took longer than expected to show nitrogen retention results. Will continue the protocol. Verified purchase from Austria.
Product quality seems fine but Follistatin 344 took longer than expected to show lean mass results. Will continue the protocol. Verified purchase from Denmark.
Product quality seems fine but Follistatin 344 took longer than expected to show lean mass results. Will continue the protocol. Verified purchase from Denmark.
Fast dispatch, proper cold chain, and the IGF-1 LR3 1mg reconstituted perfectly. Results speak for themselves — cell proliferation is remarkable.
Verified purchase — Singapore
Third order of IGF-1 LR3 1mg and consistent quality every time. nitrogen retention is the main reason I keep coming back.
Verified purchase — Switzerland
IGF-1 LR3 1mg is doing the job for my research purposes. recovery speed is the primary outcome I’m tracking and it’s moving in the right direction.
Verified purchase — Canada
Good experience with IGF-1 LR3 1mg. muscle protein synthesis improvements are noticeable though took a bit longer than expected. Quality is solid. Verified purchase from Australia.
Good experience with IGF-1 LR3 1mg. muscle protein synthesis improvements are noticeable though took a bit longer than expected. Quality is solid. Verified purchase from Australia.
Solid product overall. Follistatin 344 delivered on myostatin inhibition within about 4-5 weeks. Packaging could be slightly more insulated. Verified purchase from Finland.
Solid product overall. Follistatin 344 delivered on myostatin inhibition within about 4-5 weeks. Packaging could be slightly more insulated. Verified purchase from Finland.
Good experience with Follistatin 344. myostatin inhibition improvements are noticeable though took a bit longer than expected. Quality is solid. Verified purchase from Ireland.
Good experience with Follistatin 344. myostatin inhibition improvements are noticeable though took a bit longer than expected. Quality is solid. Verified purchase from Ireland.
IGF-1 LR3 1mg exceeded my expectations. Noticed muscle protein synthesis improvements within the first two weeks. Reordering immediately. Verified purchase from Czech Republic.
IGF-1 LR3 1mg exceeded my expectations. Noticed muscle protein synthesis improvements within the first two weeks. Reordering immediately. Verified purchase from Czech Republic.
Been using IGF-1 LR3 1mg for 3 months now. The quality is clearly top-tier — recovery speed has been noticeably better. Fast shipping too.
Verified purchase — South Korea
IGF-1 LR3 1mg exceeded my expectations. Noticed nitrogen retention improvements within the first two weeks. Reordering immediately. Verified purchase from Denmark.
IGF-1 LR3 1mg exceeded my expectations. Noticed nitrogen retention improvements within the first two weeks. Reordering immediately. Verified purchase from Denmark.
IGF-1 LR3 1mg is doing the job for my research purposes. nitrogen retention is the primary outcome I’m tracking and it’s moving in the right direction.
Verified purchase — South Korea