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Growth Hormone

Ipamorelin

Selective GHRP

Selective GH secretagogue. Stimulates GH release without elevating cortisol or prolactin — cleaner GH stimulus than older GHRPs. Stack with CJC-1295 for synergistic GH amplification.

Amino Acids5 (pentapeptide)
Mol. Weight711.9 Da
Half-Life~2 hours
Availability 🔔 By Request
Amino Acid Sequence Aib-His-D-2Nal-D-Phe-Lys-NH₂

What Is Ipamorelin?

Ipamorelin is a selective pentapeptide growth hormone releasing peptide (GHRP) that agonises the GHSR-1a (ghrelin receptor) in the pituitary and hypothalamus. Unlike GHRP-6 and GHRP-2, ipamorelin does not significantly elevate cortisol, ACTH, or prolactin — making it the cleanest GHRP for research use.

Key Mechanisms

  • GHSR-1a agonism — stimulates pituitary GH secretion in a dose-dependent manner
  • Pulse frequency increase — increases the frequency of natural GH pulses without disrupting the pulsatile pattern
  • Ghrelin-independent selectivity — no significant cortisol or prolactin release at research doses

Key References

  1. Raun K et al. “Ipamorelin, the first selective growth hormone secretagogue.” Eur J Endocrinol, 1998;139:552–561.
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