Aanvullende informatie
| Pack Size | 1 Vial, 10 Pack, 5 Pack |
|---|
Research Use Only
NAD+ 200mg
€ 56
| Quantity | Unit price | Savings |
|---|---|---|
| 1–4 units | € 70 | Base |
| 5–9 units | € 60 | −15% |
| 10+ units | € 56 | −20% |
Worldwide Shipping
Secure Checkout
Full COA Included
Ships within 24h
≥99% HPLC Purity
Research Grade
Cold-Chain Shipped
Research Use Only
NAD+ (Nicotinamide Adenine Dinucleotide) is the central electron carrier of cellular metabolism and the obligate substrate for sirtuins (SIRT1–7), PARPs, and CD38 — three enzyme families that together regulate DNA repair, mitochondrial efficiency, circadian biology, inflammatory response, and metabolic homeostasis. NAD+ levels decline by approximately 50% between ages 40 and 60, a decline now considered one of the primary molecular drivers of biological aging. Direct NAD+ supplementation is the gold-standard research tool for studying sirtuin activation, mitochondrial rejuvenation, and DNA repair kinetics in aging models.
≥99%HPLC Purity
100mgPer Vial
80+Years Researched
CoenzymeStructure
Research Data
Research Snapshot — NAD+
Key Mechanisms & Pathways
- Sirtuin Activation (SIRT1-7)All 7 sirtuins require NAD+ as obligate cofactor; SIRT1 activates PGC-1α (mitochondrial biogenesis), SIRT3 maintains ETC, SIRT6 preserves genomic stability.
- PARP-Mediated DNA RepairPARP1/2 consume NAD+ to repair up to 70,000 single-strand DNA breaks per cell per day via poly(ADP-ribose) synthesis.
- Complex I Electron TransportNADH (reduced NAD+) is the electron donor for Complex I — the rate-limiting step of mitochondrial ATP production.
- CD38 CompetitionCD38 NADase expression rises with age/inflammation (inflammaging); NAD+ repletion offsets this consumption and restores sirtuin activity.
- AMPK Cross-TalkVia SIRT1 → LKB1 → AMPK signalling, elevated NAD+ promotes repair and catabolic states — the metabolic signature of longevity.
- Circadian Clock RegulationSIRT1 deacetylates BMAL1 and PER2 — core clock proteins — linking NAD+ levels directly to circadian rhythm quality.
Preclinical & Clinical Research Summary
| Research Area | Key Finding | Source |
|---|---|---|
| Muscle Rejuvenation | Restored muscle mass, strength and mitochondrial density in aged mice to levels of young controls. | Gomes AP et al., 2013 — Cell |
| DNA Repair Restoration | Reversed γH2AX/8-OHdG DNA damage markers; improved radiation survival in aged mice. | Li J et al., 2017 — Science |
| Metabolic Health | NAD+ precursor NMN improved glucose tolerance, lipid metabolism and energy expenditure in obese mice. | Yoshino J et al., 2011 — Cell Metab |
| Human Clinical Trial | 250mg NMN/day for 10 weeks increased skeletal muscle NAD+ and improved insulin sensitivity in prediabetic women. | Yoshino M et al., 2021 — Science |
References
- Gomes AP et al. “Declining NAD+ induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging.” Cell, 2013;155(7):1624–1638.
- Yoshino J et al. “Nicotinamide mononucleotide, a key NAD+ intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice.” Cell Metab, 2011;14(4):528–536.
- Verdin E. “NAD+ in aging, metabolism, and neurodegeneration.” Science, 2015;350(6265):1208–1213.
- Yoshino M et al. “Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women.” Science, 2021;372(6547):1224–1229.
Chemical & Physical Details
CAS Number
53-84-9
Molecular Formula
C₂₁H₂₇N₇O₁₄P₂
Molecular Weight
663.43 g/mol
Purity
≥99% (HPLC)
Appearance
White to off-white lyophilized powder
Solubility
Freely soluble in water (≥100 mg/mL)
Storage
-20 °C. Protect from light and moisture.
Format
Lyophilized Powder
Retest Date
2027-03-05
Certificate of Analysis
Verify This Batch
Batch DP-2026-NAD-001
| Test | Specification | Result | Method | Status |
|---|---|---|---|---|
| Appearance | White/off-white powder | White/off-white powder | Visual | PASS |
| Identity (MS) | Conforms to reference | Confirmed | LC-MS/MS | PASS |
| Purity (HPLC) | ≥99.0% | 99.6% | RP-HPLC | PASS |
| Assay (Content) | 95.0–105.0% | 99.4% | HPLC | PASS |
| Bacterial Endotoxins | <5.0 EU/mg | <0.5 EU/mg | LAL | PASS |
| Heavy Metals | <20 ppm | <7 ppm | ICP-MS | PASS |
| Residual Solvents | ICH Q3C limits | Not Detected | GC-HS | PASS |
| Moisture (LOD) | ≤6.0% | 2.2% | Karl Fischer | PASS |
PASS — Released for research use
This Certificate of Analysis is provided for research transparency purposes only. All products are supplied for in vitro research use only and are not intended for human or veterinary administration. Verify batch DP-2026-NAD-001 online →
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Research Use Only — Important Notice
For in vitro research use only. Not for human or veterinary use. Not intended to diagnose, treat, cure, or prevent any disease or condition. This product is supplied exclusively for qualified in vitro research. Purchasing this product confirms you are a qualified researcher and will use it accordingly. Learn about our quality standards →
For in vitro research use only. Not for human or veterinary use. Not intended to diagnose, treat, cure, or prevent any disease or condition. This product is supplied exclusively for qualified in vitro research. Purchasing this product confirms you are a qualified researcher and will use it accordingly. Learn about our quality standards →
Peptide Encyclopedia — 28 Compounds
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BPC-157
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Cerebrolysin
Cognitive
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CJC-1295
Growth Hormone
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Dihexa
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DSIP (Delta Sleep-Inducing Peptide)
Sleep
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Epithalon (Epitalon)
Anti-Aging & Longevity
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GHK-Cu (Copper Peptide)
Healing & Recovery
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HCG (Human Chorionic Gonadotropin)
Hormones
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HGH Somatropin
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IGF-1 LR3
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Ipamorelin
Growth Hormone
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Kisspeptin-10
Hormones
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LL-37 (Cathelicidin)
Immune
💊
Melanotan II
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MOTS-C
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Anti-Aging & Longevity
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Oxytocin
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PT-141 (Bremelanotide)
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Retatrutide (LY3437943)
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Selank
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Semaglutide
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Semax
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SS-31 (Elamipretide)
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TB500 (Thymosin Beta-4)
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Thymosin Alpha-1 (Tα1)
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Tirzepatide
Metabolic
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VIP (Vasoactive Intestinal Peptide)
Immune
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Nederlands
Research grade quality as advertised. NAD+ 100mg is exactly what I needed for my energy metabolism study. COA provided without asking.
Verified purchase — Belgium
Outstanding product. NAD+ 100mg arrived cold-packed, well within spec. My mitochondrial function protocol has never been more effective.
Verified purchase — Finland
Been using NAD+ 100mg for 3 months now. The quality is clearly top-tier — mitochondrial function has been noticeably better. Fast shipping too.
Verified purchase — Denmark
Fast dispatch, proper cold chain, and NAD+ 100mg reconstituted perfectly. energy metabolism results match the literature exactly. Verified purchase from Netherlands.
Fast dispatch, proper cold chain, and NAD+ 100mg reconstituted perfectly. energy metabolism results match the literature exactly. Verified purchase from Netherlands.
Outstanding product. NAD+ 100mg arrived cold-packed, well within spec. My mitochondrial function protocol has never been more effective.
Verified purchase — Netherlands
Happy with my NAD+ 100mg purchase. Shipping was fast and energy metabolism protocol is progressing well. Great product overall. Verified purchase from France.
Happy with my NAD+ 100mg purchase. Shipping was fast and energy metabolism protocol is progressing well. Great product overall. Verified purchase from France.
Good experience with NAD+ 100mg. longevity markers improvements are noticeable though took a bit longer than expected. Quality seems solid.
Verified purchase — Singapore
Best vendor I have tried for NAD+ 100mg. Purity is clearly above average and cellular repair results prove it over a 8 week run. Verified purchase from Norway.
Best vendor I have tried for NAD+ 100mg. Purity is clearly above average and cellular repair results prove it over a 8 week run. Verified purchase from Norway.
My go-to source for NAD+ 100mg. The cognitive clarity improvements are consistent across batches which tells me QC is taken seriously. Verified purchase from France.
My go-to source for NAD+ 100mg. The cognitive clarity improvements are consistent across batches which tells me QC is taken seriously. Verified purchase from France.
NAD+ 100mg arrived cold-packed, well within spec. My cognitive clarity protocol has never been more effective. Verified purchase from United Kingdom.
NAD+ 100mg arrived cold-packed, well within spec. My cognitive clarity protocol has never been more effective. Verified purchase from United Kingdom.
Fast dispatch, proper cold chain, and NAD+ 100mg reconstituted perfectly. cognitive clarity results match the literature exactly. Verified purchase from Czech Republic.
Fast dispatch, proper cold chain, and NAD+ 100mg reconstituted perfectly. cognitive clarity results match the literature exactly. Verified purchase from Czech Republic.
As a researcher, I’m very particular about purity. The COA for NAD+ 100mg checked out perfectly at 99.2%. Excellent product.
Verified purchase — Switzerland
Incredible results with NAD+ 100mg. After 6 weeks I noticed significant improvements in longevity markers. Will definitely reorder.
Verified purchase — Australia
Outstanding product. NAD+ 100mg arrived cold-packed, well within spec. My energy metabolism protocol has never been more effective.
Verified purchase — United Kingdom
Switched from a competitor to Decode for NAD+ 100mg. Night and day difference in energy metabolism outcomes. Staying here. Verified purchase from Canada.
Switched from a competitor to Decode for NAD+ 100mg. Night and day difference in energy metabolism outcomes. Staying here. Verified purchase from Canada.
Research grade quality as advertised. NAD+ 100mg is exactly what I needed for my cognitive clarity study. COA provided without asking.
Verified purchase — Netherlands
Fast dispatch, proper cold chain, and NAD+ 100mg reconstituted perfectly. cognitive clarity results match the literature exactly. Verified purchase from United States.
Fast dispatch, proper cold chain, and NAD+ 100mg reconstituted perfectly. cognitive clarity results match the literature exactly. Verified purchase from United States.
Very good quality NAD+ 100mg. energy metabolism has been the main focus of my research and results are promising after 8 weeks.
Verified purchase — Finland
Impressed by the professionalism. NAD+ 100mg came with full COA, proper cold packaging, and cellular repair results are measurable. Verified purchase from Netherlands.
Impressed by the professionalism. NAD+ 100mg came with full COA, proper cold packaging, and cellular repair results are measurable. Verified purchase from Netherlands.
NAD+ 100mg is decent quality but I’ve seen better longevity markers results with longer cycle durations. The purity seems fine.
Verified purchase — Ireland
Product quality seems fine but NAD+ 100mg took longer than expected to show energy metabolism results. Will continue for another month.
Verified purchase — Norway
Couldn’t be happier. NAD+ 100mg is consistently dosed and the longevity markers effects are exactly what the literature suggests.
Verified purchase — Austria
Average experience with NAD+ 100mg. cellular repair showed some improvement but nothing dramatic in my 4 week window so far. Verified purchase from France.
Average experience with NAD+ 100mg. cellular repair showed some improvement but nothing dramatic in my 4 week window so far. Verified purchase from France.
Average experience with NAD+ 100mg. mitochondrial function showed some improvement but nothing dramatic in my 4 week window.
Verified purchase — Finland
Third order of NAD+ 100mg and consistent quality every time. mitochondrial function is the main reason I keep coming back.
Verified purchase — Singapore