Cerebrolysin

What Is Cerebrolysin?

Cerebrolysin (EVER Neuro Pharma) is a peptide preparation derived from purified porcine brain proteins, containing low molecular weight neuropeptides (<1 kDa) and amino acids. Approved in 50+ countries for Alzheimer's disease, ischemic stroke, and traumatic brain injury. Mimics the effects of endogenous neurotrophic factors.

Key Mechanisms

• BDNF, NGF, GDNF mimicry — activates TrkB, TrkA and Ret receptor pathways — neurotrophic and neuroprotective
• Anti-apoptotic — reduces Bcl-2/Bax ratio favourably; prevents caspase-3 activation
• Neuroplasticity — promotes dendritic spine formation and synaptic strength
• Neurogenesis — stimulates hippocampal neurogenesis in aged models
• Neuroprotection — reduces glutamate excitotoxicity and oxidative damage post-ischemia

Key References

1. Gauthier S et al. “Cerebrolysin in Alzheimer’s disease.” Eur J Neurol, 2003;10(6):595–601.
2. Rockenstein E et al. “Cerebrolysin decreases amyloid-beta production.” J Neurosci Res, 2006;83:1252–1261.