Description
GHK-Cu (Glycine-Histidine-Lysine copper complex) was first isolated from human plasma albumin in 1973 by Pickart and Thaler. Its plasma concentration declines from ~200 ng/mL at age 20 to under 80 ng/mL by age 60 — a decline directly correlated with reduced tissue repair capacity. A landmark 2012 study demonstrated that GHK-Cu modulates the expression of 32% of the human genome, making it one of the most wide-ranging regulatory peptides ever characterised. Research applications span wound healing, skin regeneration, hair growth, pulmonary fibrosis, neural repair, and anti-cancer gene expression.
≥99%HPLC Purity
100mgPer Vial
50+Years Researched
3 aaStructure
Research Data
Research Snapshot — GHK-Cu (Copper Peptide)
Key Mechanisms & Pathways
- Collagen I, III & VI SynthesisUpregulates COL1A1, COL3A1 and decorin — structural collagen genes critical for skin, tendon and wound repair.
- Genomic ReprogrammingModulates expression of 32% of the human genome via VEGF, HGF and anti-inflammatory cytokine gene activation.
- MMP / TIMP BalanceSimultaneously activates MMPs for remodelling and TIMPs for protection — balanced ECM turnover, not degradation.
- Copper-SOD ActivationDelivers Cu²⁺ to superoxide dismutase and lysyl oxidase, driving antioxidant defence and collagen crosslinking.
- VEGF & FGF-2 InductionStimulates angiogenic and fibroblast growth factors, accelerating wound vascularisation and closure.
- Neural RegenerationPromotes axonal outgrowth and BDNF expression; used in CNS injury and neuropathy research models.
Preclinical & Clinical Research Summary
| Research Area | Key Finding | Source |
|---|---|---|
| Skin Regeneration | Increased skin thickness by 120% and collagen density by 70% in aged skin models. | Abdulghani AA et al., 1998 — J Dermatol Surg |
| Wound Healing | Accelerated healing of chronic leg ulcers; improved wound contraction rates clinically. | Leyden JJ et al., 1990 |
| Hair Growth | Enlarged follicle size; increased KGF (keratinocyte growth factor) expression in vivo. | Uno H et al., 1996 |
| Lung Protection | Attenuated bleomycin-induced pulmonary fibrosis by reducing TGF-β1 and collagen deposition. | Campbell JD et al., 2019 |
References
- Pickart L et al. “The human tripeptide GHK-Cu in prevention of oxidative stress and degenerative conditions of aging.” Oxid Med Cell Longev, 2012;2012:324832.
- Pickart L, Margolina A. “Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data.” Int J Mol Sci, 2018;19(7):1987.
- Gorouhi F, Maibach HI. “Role of topical peptides in preventing or treating aged skin.” Int J Cosmet Sci, 2009;31(5):327–345.
- Canapp SO et al. “The effect of topical tripeptide-copper complex on healing of ischemic open wounds.” Vet Surg, 2003;32(6):515–523.
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Product quality seems fine but GHK-Cu (Copper Peptide) 100mg took longer than expected to show anti-aging markers results. Will continue the protocol.
Verified purchase — Ireland
Average experience with GHK-Cu (Copper Peptide) 100mg. anti-aging markers showed some improvement but nothing dramatic in my 4 week window so far. Verified purchase from Ireland.
Average experience with GHK-Cu (Copper Peptide) 100mg. anti-aging markers showed some improvement but nothing dramatic in my 4 week window so far. Verified purchase from Ireland.
Outstanding vendor. GHK-Cu (Copper Peptide) 100mg purity is verifiable, shipping was 2 days, and collagen synthesis effects are undeniable at week 4. Verified purchase from Australia.
Outstanding vendor. GHK-Cu (Copper Peptide) 100mg purity is verifiable, shipping was 2 days, and collagen synthesis effects are undeniable at week 4. Verified purchase from Australia.
Fast dispatch, proper cold chain, and GHK-Cu (Copper Peptide) 100mg reconstituted perfectly. anti-aging markers results match the literature exactly. Verified purchase from Italy.
Fast dispatch, proper cold chain, and GHK-Cu (Copper Peptide) 100mg reconstituted perfectly. anti-aging markers results match the literature exactly. Verified purchase from Italy.
GHK-Cu (Copper Peptide) 100mg is decent quality but I have seen better wound healing results with longer cycle durations. Purity seems fine. Verified purchase from Netherlands.
GHK-Cu (Copper Peptide) 100mg is decent quality but I have seen better wound healing results with longer cycle durations. Purity seems fine. Verified purchase from Netherlands.
Very good quality GHK-Cu (Copper Peptide) 100mg. collagen synthesis has been the main focus of my research and results are promising after 8 weeks. Verified purchase from United States.
Very good quality GHK-Cu (Copper Peptide) 100mg. collagen synthesis has been the main focus of my research and results are promising after 8 weeks. Verified purchase from United States.
LL-37 exceeded my expectations. Noticed innate immunity improvements within the first two weeks. Reordering immediately. Verified purchase from Singapore.
LL-37 exceeded my expectations. Noticed innate immunity improvements within the first two weeks. Reordering immediately. Verified purchase from Singapore.
Switched from a competitor to Decode for LL-37. Night and day difference in antimicrobial defense outcomes. Staying here. Verified purchase from Italy.
Switched from a competitor to Decode for LL-37. Night and day difference in antimicrobial defense outcomes. Staying here. Verified purchase from Italy.
Research grade quality as advertised. GHK-Cu (Copper Peptide) 100mg is exactly what I needed for my collagen synthesis study. COA provided without asking.
Verified purchase — Denmark
Good experience with GHK-Cu (Copper Peptide) 100mg. collagen synthesis improvements are noticeable though took a bit longer than expected. Quality is solid. Verified purchase from Germany.
Good experience with GHK-Cu (Copper Peptide) 100mg. collagen synthesis improvements are noticeable though took a bit longer than expected. Quality is solid. Verified purchase from Germany.
Impressed by the professionalism. LL-37 came with full COA, proper cold packaging, and innate immunity results are measurable. Verified purchase from Sweden.
Impressed by the professionalism. LL-37 came with full COA, proper cold packaging, and innate immunity results are measurable. Verified purchase from Sweden.
Third order of GHK-Cu (Copper Peptide) 100mg and consistent quality every time. collagen synthesis is the main reason I keep coming back.
Verified purchase — Finland
Solid product overall. GHK-Cu (Copper Peptide) 100mg delivered on skin regeneration within about 4-5 weeks. Packaging could be slightly better but quality is fine.
Verified purchase — Ireland
Product quality seems fine but GHK-Cu (Copper Peptide) 100mg took longer than expected to show collagen synthesis results. Will continue the protocol. Verified purchase from Singapore.
Product quality seems fine but GHK-Cu (Copper Peptide) 100mg took longer than expected to show collagen synthesis results. Will continue the protocol. Verified purchase from Singapore.
I’ve tried several vendors for GHK-Cu (Copper Peptide) 100mg — Decode is by far the most reliable. Purity is what you pay for and it shows.
Verified purchase — United States
My go-to source for LL-37. The innate immunity improvements are consistent across batches which tells me QC is taken seriously. Verified purchase from Belgium.
My go-to source for LL-37. The innate immunity improvements are consistent across batches which tells me QC is taken seriously. Verified purchase from Belgium.
GHK-Cu (Copper Peptide) 100mg is doing the job. collagen synthesis is the primary outcome I track and it is trending the right way after 6 weeks. Verified purchase from Norway.
GHK-Cu (Copper Peptide) 100mg is doing the job. collagen synthesis is the primary outcome I track and it is trending the right way after 6 weeks. Verified purchase from Norway.
Incredible results with GHK-Cu (Copper Peptide) 100mg. After 6 weeks I noticed significant improvements in tissue remodeling. Will definitely reorder.
Verified purchase — Sweden
Fast dispatch, proper cold chain, and the GHK-Cu (Copper Peptide) 100mg reconstituted perfectly. Results speak for themselves — tissue remodeling is remarkable.
Verified purchase — New Zealand