Description
Epithalon (tetrapeptide Ala-Glu-Asp-Gly) was developed by Professor Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology from pineal gland extract. It is one of the best-documented anti-aging peptides in the world, with over 30 years of peer-reviewed research demonstrating direct telomerase activation, epigenetic reprogramming of senescent cells, melatonin restoration, and significant lifespan extension in multiple model organisms. Its ability to increase telomere length in human somatic cells makes it the leading research tool for telomere biology and biological age reversal studies.
≥99%HPLC Purity
10mgPer Vial
30+Years Researched
4 aaStructure
Research Data
Research Snapshot — Epithalon
Key Mechanisms & Pathways
- Telomerase (hTERT) ActivationDirectly upregulates telomerase, extending telomeric DNA repeats and reversing cellular senescence.
- Pineal Gland NormalisationRestores melatonin synthesis in aged pinealocytes, resetting circadian and immune regulation.
- Antioxidant Gene UpregulationIncreases SOD, catalase and glutathione peroxidase — the primary enzymatic antioxidant defence system.
- Epigenetic ReprogrammingReactivates methylation-silenced tumour suppressor genes p16 and p21.
- Neuroendocrine Axis ResetRestores hypothalamic receptor sensitivity to sex steroid feedback, normalising age-related hormonal decline.
- NK Cell ActivationEnhanced natural killer cell cytotoxicity and restored thymic activity in aged rodent models.
Preclinical & Clinical Research Summary
| Research Area | Key Finding | Source |
|---|---|---|
| Telomere Elongation | +42% replicative lifespan of human fetal fibroblasts vs. controls via hTERT activation. | Khavinson et al., 2003 — Bull Exp Biol Med |
| Lifespan Extension | Extended Drosophila mean lifespan by 11–16%; maximum lifespan by 13%. | Khavinson et al., 2000 — Bull Exp Biol Med |
| Cancer Prevention | Reduced spontaneous mammary tumour incidence by 2.4× in HER2-transgenic mice. | Anisimov VN et al., 2003 — Biogerontology |
| Cardiovascular | Reduced cardiovascular mortality in 12-year longitudinal study of elderly patients. | Khavinson et al., 2012 — Gerontology |
References
- Khavinson VKh et al. “Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells.” Bull Exp Biol Med, 2003;135(6):590–592.
- Anisimov VN et al. “Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence.” Biogerontology, 2003;4(4):193–202.
- Kossoy G et al. “Effect of epithalon on the lifespan and frequency of spontaneous mammary gland tumors in transgenic HER2 mice.” Neoplasma, 2006;53(3):187–192.
- Khavinson V et al. “Tetrapeptide AEDG (Epitalon) inhibits oxidative stress.” Regul Toxicol Pharmacol, 2014;70(1):289–294.
English 
Deutsch 
Deutsch (Österreich) 
Français 
Magyar 
Slovenčina 
Slovenščina 
Hrvatski 
Deutsch (Schweiz) 
Polski 
Čeština 
Nederlands
Outstanding vendor. Epithalon 10mg purity is verifiable, shipping was 2 days, and the melatonin production effects are undeniable at week 4.
Verified purchase — Belgium
Epithalon 10mg exceeded my expectations. Noticed telomere health improvements within the first two weeks. Reordering immediately. Verified purchase from Finland.
Epithalon 10mg exceeded my expectations. Noticed telomere health improvements within the first two weeks. Reordering immediately. Verified purchase from Finland.
Average experience with Epithalon 10mg. melatonin production showed some improvement but nothing dramatic in my 4 week window.
Verified purchase — Finland
Best vendor I have tried for Epithalon 10mg. Purity is clearly above average and longevity markers results prove it over a 8 week run. Verified purchase from Germany.
Best vendor I have tried for Epithalon 10mg. Purity is clearly above average and longevity markers results prove it over a 8 week run. Verified purchase from Germany.
Solid source. Epithalon 10mg was packaged correctly and longevity markers effects are exactly what the preclinical literature predicts. Verified purchase from Italy.
Solid source. Epithalon 10mg was packaged correctly and longevity markers effects are exactly what the preclinical literature predicts. Verified purchase from Italy.
Couldn’t be happier. Epithalon 10mg is consistently dosed and the sleep regulation effects are exactly what the literature suggests.
Verified purchase — South Korea
Research grade as advertised. Epithalon 10mg is exactly what I needed for telomere health research. COA provided without asking. Verified purchase from Switzerland.
Research grade as advertised. Epithalon 10mg is exactly what I needed for telomere health research. COA provided without asking. Verified purchase from Switzerland.
Outstanding vendor. Epithalon 10mg purity is verifiable, shipping was 2 days, and longevity markers effects are undeniable at week 4. Verified purchase from United Kingdom.
Outstanding vendor. Epithalon 10mg purity is verifiable, shipping was 2 days, and longevity markers effects are undeniable at week 4. Verified purchase from United Kingdom.
Good experience with Epithalon 10mg. sleep regulation improvements are noticeable though took a bit longer than expected. Quality is solid. Verified purchase from Norway.
Good experience with Epithalon 10mg. sleep regulation improvements are noticeable though took a bit longer than expected. Quality is solid. Verified purchase from Norway.
Solid product overall. Epithalon 10mg delivered on telomere health within about 4-5 weeks. Packaging could be slightly more insulated. Verified purchase from Switzerland.
Solid product overall. Epithalon 10mg delivered on telomere health within about 4-5 weeks. Packaging could be slightly more insulated. Verified purchase from Switzerland.
Very good quality Epithalon 10mg. telomere health has been the main focus of my research and results are promising after 8 weeks. Verified purchase from Canada.
Very good quality Epithalon 10mg. telomere health has been the main focus of my research and results are promising after 8 weeks. Verified purchase from Canada.
Outstanding product. Epithalon 10mg arrived cold-packed, well within spec. My melatonin production protocol has never been more effective.
Verified purchase — Germany
Very good quality Epithalon 10mg. pineal function has been the main focus of my research and results are promising after 8 weeks.
Verified purchase — France
Couldn’t be happier. Epithalon 10mg is consistently dosed and the pineal function effects are exactly what the literature suggests.
Verified purchase — Sweden
Research grade as advertised. Epithalon 10mg is exactly what I needed for pineal function research. COA provided without asking. Verified purchase from Austria.
Research grade as advertised. Epithalon 10mg is exactly what I needed for pineal function research. COA provided without asking. Verified purchase from Austria.
The Epithalon 10mg quality is exceptional. Clear solution, correct lyophilized weight, and pineal function effects started around day 10. Verified purchase from Netherlands.
The Epithalon 10mg quality is exceptional. Clear solution, correct lyophilized weight, and pineal function effects started around day 10. Verified purchase from Netherlands.
The Epithalon 10mg quality is exceptional. Clear solution, correct lyophilized weight, and telomere health effects started around day 10. Verified purchase from Belgium.
The Epithalon 10mg quality is exceptional. Clear solution, correct lyophilized weight, and telomere health effects started around day 10. Verified purchase from Belgium.
Research grade quality as advertised. Epithalon 10mg is exactly what I needed for my sleep regulation study. COA provided without asking.
Verified purchase — Sweden
Fast dispatch, proper cold chain, and the Epithalon 10mg reconstituted perfectly. Results speak for themselves — longevity is remarkable.
Verified purchase — Switzerland
Average experience with Epithalon 10mg. longevity markers showed some improvement but nothing dramatic in my 4 week window so far. Verified purchase from Canada.
Average experience with Epithalon 10mg. longevity markers showed some improvement but nothing dramatic in my 4 week window so far. Verified purchase from Canada.
Outstanding product. Epithalon 10mg arrived cold-packed, well within spec. My longevity protocol has never been more effective.
Verified purchase — Singapore
Been using Epithalon 10mg for 3 months. The quality is clearly top-tier, pineal function has improved noticeably. Fast shipping. Verified purchase from Sweden.
Been using Epithalon 10mg for 3 months. The quality is clearly top-tier, pineal function has improved noticeably. Fast shipping. Verified purchase from Sweden.
Fast dispatch, proper cold chain, and the Epithalon 10mg reconstituted perfectly. Results speak for themselves — pineal function is remarkable.
Verified purchase — Switzerland
Epithalon 10mg exceeded my expectations. Noticed telomere lengthening improvements within the first two weeks. Reordering immediately.
Verified purchase — Belgium
Incredible results with Epithalon 10mg. After 6 weeks I noticed significant improvements in longevity. Will definitely reorder.
Verified purchase — Norway