Beschreibung
NAD+ (Nicotinamide Adenine Dinucleotide) is the central electron carrier of cellular metabolism and the obligate substrate for sirtuins (SIRT1–7), PARPs, and CD38 — three enzyme families that together regulate DNA repair, mitochondrial efficiency, circadian biology, inflammatory response, and metabolic homeostasis. NAD+ levels decline by approximately 50% between ages 40 and 60, a decline now considered one of the primary molecular drivers of biological aging. Direct NAD+ supplementation is the gold-standard research tool for studying sirtuin activation, mitochondrial rejuvenation, and DNA repair kinetics in aging models.
≥99%HPLC-Reinheit
100mgVon Vial
80+Jahre der Recherche
CoenzymStruktur
Forschungsdaten
Research Snapshot — NAD+
Schlüsselmechanismen und Signalwege
- Sirtuin Activation (SIRT1-7)All 7 sirtuins require NAD+ as obligate cofactor; SIRT1 activates PGC-1α (mitochondrial biogenesis), SIRT3 maintains ETC, SIRT6 preserves genomic stability.
- PARP-Mediated DNA RepairPARP1/2 consume NAD+ to repair up to 70,000 single-strand DNA breaks per cell per day via poly(ADP-ribose) synthesis.
- Complex I Electron TransportNADH (reduced NAD+) is the electron donor for Complex I — the rate-limiting step of mitochondrial ATP production.
- CD38 CompetitionCD38 NADase expression rises with age/inflammation (inflammaging); NAD+ repletion offsets this consumption and restores sirtuin activity.
- AMPK Cross-TalkVia SIRT1 → LKB1 → AMPK signalling, elevated NAD+ promotes repair and catabolic states — the metabolic signature of longevity.
- Circadian Clock RegulationSIRT1 deacetylates BMAL1 and PER2 — core clock proteins — linking NAD+ levels directly to circadian rhythm quality.
Zusammenfassung der präklinischen und klinischen Forschung
| Forschungsgebiet | Wichtigste Erkenntnis | Quelle |
|---|---|---|
| Muscle Rejuvenation | Restored muscle mass, strength and mitochondrial density in aged mice to levels of young controls. | Gomes AP et al., 2013 — Cell |
| DNA Repair Restoration | Reversed γH2AX/8-OHdG DNA damage markers; improved radiation survival in aged mice. | Li J et al., 2017 — Science |
| Stoffwechselgesundheit | NAD+ precursor NMN improved glucose tolerance, lipid metabolism and energy expenditure in obese mice. | Yoshino J et al., 2011 — Cell Metab |
| Human Clinical Trial | 250mg NMN/day for 10 weeks increased skeletal muscle NAD+ and improved insulin sensitivity in prediabetic women. | Yoshino M et al., 2021 — Science |
Referenzen
- Gomes AP et al. “Declining NAD+ induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging.” Cell, 2013;155(7):1624–1638.
- Yoshino J et al. “Nicotinamide mononucleotide, a key NAD+ intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice.” Cell Metab, 2011;14(4):528–536.
- Verdin E. “NAD+ in aging, metabolism, and neurodegeneration.” Science, 2015;350(6265):1208–1213.
- Yoshino M et al. “Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women.” Science, 2021;372(6547):1224–1229.
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Research grade quality as advertised. NAD+ 100mg is exactly what I needed for my energy metabolism study. COA provided without asking.
Verifizierter Kauf – Belgien
Outstanding product. NAD+ 100mg arrived cold-packed, well within spec. My mitochondrial function protocol has never been more effective.
Verifizierter Kauf – Finnland
Been using NAD+ 100mg for 3 months now. The quality is clearly top-tier — mitochondrial function has been noticeably better. Fast shipping too.
Verified purchase — Denmark
Fast dispatch, proper cold chain, and NAD+ 100mg reconstituted perfectly. energy metabolism results match the literature exactly. Verified purchase from Netherlands.
Fast dispatch, proper cold chain, and NAD+ 100mg reconstituted perfectly. energy metabolism results match the literature exactly. Verified purchase from Netherlands.
Outstanding product. NAD+ 100mg arrived cold-packed, well within spec. My mitochondrial function protocol has never been more effective.
Verified purchase — Netherlands
Happy with my NAD+ 100mg purchase. Shipping was fast and energy metabolism protocol is progressing well. Great product overall. Verified purchase from France.
Happy with my NAD+ 100mg purchase. Shipping was fast and energy metabolism protocol is progressing well. Great product overall. Verified purchase from France.
Good experience with NAD+ 100mg. longevity markers improvements are noticeable though took a bit longer than expected. Quality seems solid.
Verifizierter Kauf – Singapur
Best vendor I have tried for NAD+ 100mg. Purity is clearly above average and cellular repair results prove it over a 8 week run. Verified purchase from Norway.
Best vendor I have tried for NAD+ 100mg. Purity is clearly above average and cellular repair results prove it over a 8 week run. Verified purchase from Norway.
My go-to source for NAD+ 100mg. The cognitive clarity improvements are consistent across batches which tells me QC is taken seriously. Verified purchase from France.
My go-to source for NAD+ 100mg. The cognitive clarity improvements are consistent across batches which tells me QC is taken seriously. Verified purchase from France.
Die 100 mg NAD+ kamen gekühlt und innerhalb der Spezifikationen an. Mein Programm zur Verbesserung der kognitiven Leistungsfähigkeit war noch nie so effektiv. Verifizierter Kauf aus Großbritannien.
Die 100 mg NAD+ kamen gekühlt und innerhalb der Spezifikationen an. Mein Programm zur Verbesserung der kognitiven Leistungsfähigkeit war noch nie so effektiv. Verifizierter Kauf aus Großbritannien.
Fast dispatch, proper cold chain, and NAD+ 100mg reconstituted perfectly. cognitive clarity results match the literature exactly. Verified purchase from Czech Republic.
Fast dispatch, proper cold chain, and NAD+ 100mg reconstituted perfectly. cognitive clarity results match the literature exactly. Verified purchase from Czech Republic.
As a researcher, I’m very particular about purity. The COA for NAD+ 100mg checked out perfectly at 99.2%. Excellent product.
Verified purchase — Switzerland
Incredible results with NAD+ 100mg. After 6 weeks I noticed significant improvements in longevity markers. Will definitely reorder.
Verified purchase — Australia
Outstanding product. NAD+ 100mg arrived cold-packed, well within spec. My energy metabolism protocol has never been more effective.
Verifizierter Kauf – Vereinigtes Königreich
Switched from a competitor to Decode for NAD+ 100mg. Night and day difference in energy metabolism outcomes. Staying here. Verified purchase from Canada.
Switched from a competitor to Decode for NAD+ 100mg. Night and day difference in energy metabolism outcomes. Staying here. Verified purchase from Canada.
Research grade quality as advertised. NAD+ 100mg is exactly what I needed for my cognitive clarity study. COA provided without asking.
Verified purchase — Netherlands
Fast dispatch, proper cold chain, and NAD+ 100mg reconstituted perfectly. cognitive clarity results match the literature exactly. Verified purchase from United States.
Fast dispatch, proper cold chain, and NAD+ 100mg reconstituted perfectly. cognitive clarity results match the literature exactly. Verified purchase from United States.
Very good quality NAD+ 100mg. energy metabolism has been the main focus of my research and results are promising after 8 weeks.
Verifizierter Kauf – Finnland
Impressed by the professionalism. NAD+ 100mg came with full COA, proper cold packaging, and cellular repair results are measurable. Verified purchase from Netherlands.
Impressed by the professionalism. NAD+ 100mg came with full COA, proper cold packaging, and cellular repair results are measurable. Verified purchase from Netherlands.
NAD+ 100mg is decent quality but I’ve seen better longevity markers results with longer cycle durations. The purity seems fine.
Verifizierter Kauf – Irland
Product quality seems fine but NAD+ 100mg took longer than expected to show energy metabolism results. Will continue for another month.
Verifizierter Kauf – Norwegen
Couldn’t be happier. NAD+ 100mg is consistently dosed and the longevity markers effects are exactly what the literature suggests.
Verifizierter Kauf – Österreich
Average experience with NAD+ 100mg. cellular repair showed some improvement but nothing dramatic in my 4 week window so far. Verified purchase from France.
Average experience with NAD+ 100mg. cellular repair showed some improvement but nothing dramatic in my 4 week window so far. Verified purchase from France.
Average experience with NAD+ 100mg. mitochondrial function showed some improvement but nothing dramatic in my 4 week window.
Verifizierter Kauf – Finnland
Dritte Bestellung von NAD+ 100 mg und jedes Mal gleichbleibende Qualität. Die Verbesserung der Mitochondrienfunktion ist der Hauptgrund, warum ich immer wieder darauf zurückgreife.
Verifizierter Kauf – Singapur