Description
Oxytocin (Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly; MW 1007 Da) is a nonapeptide synthesised in the hypothalamic PVN and SON and released both peripherally (posterior pituitary) and centrally (axonal projections to amygdala, NAc, hippocampus, brainstem). It is one of the most evolutionarily conserved peptides in vertebrate neuroscience, with functional homologues from nematodes to primates. Oxytocin’s central roles in social bonding, trust, fear reduction, sexual function, and reproductive physiology make it the primary research tool for social neuroscience, reproductive endocrinology, ASD, PTSD, and attachment biology.
≥99%HPLC Purity
2mgPer Vial
70+Years Researched
9 aaStructure
Research Data
Research Snapshot — Oxytocin
Key Mechanisms & Pathways
- OTR / Gq / PLC / IP3Gq-coupled OTR → PLC activation → IP3-mediated Ca²⁺ release and DAG/PKC activation — the universal OTR intracellular cascade.
- Mesolimbic DopamineOTR in nucleus accumbens potentiates D2 receptor signalling — the neurochemical basis of social reward and pair bonding.
- Amygdala CRF SuppressionOxytocinergic PVN→CeA projections suppress corticotropin-releasing factor release, reducing anxiety and fear conditioning.
- Serotonin Cross-TalkBidirectional feedback with dorsal raphe 5-HT release; regulates social affiliation and prosocial motivation.
- Reproductive NeuroendocrineTriggers uterine contraction (parturition), milk ejection (lactation), and smooth muscle contraction in vas deferens during ejaculation.
- Immune ModulationOTR on T-lymphocytes and macrophages reduces TNF-α and IL-6 production; anti-inflammatory in LPS challenge models.
Preclinical & Clinical Research Summary
| Research Area | Key Finding | Source |
|---|---|---|
| Social Trust | Intranasal oxytocin (24 IU) significantly increased trust in the Trust Game economic experiment. | Kosfeld M et al., 2005 — Nature |
| ASD / Social Cognition | Improved emotion recognition and social motivation in adults with ASD; fMRI showed CNS changes. | Guastella AJ et al., 2010 — Biol Psychiatry |
| Pair Bonding | OTR knockout in prairie voles abolished pair bond formation despite normal sexual behaviour. | Insel TR & Young LJ, 2001 — Nat Rev Neurosci |
| Sexual Function | Plasma OT surges 3–5× during orgasm; intranasal OT increased sexual satisfaction in crossover study. | Kruger THC et al., 2012 — Horm Behav |
References
- Kosfeld M et al. “Oxytocin increases trust in humans.” Nature, 2005;435(7042):673–676.
- Insel TR, Young LJ. “The neurobiology of attachment.” Nat Rev Neurosci, 2001;2(2):129–136.
- Guastella AJ et al. “Intranasal oxytocin improves emotion recognition for youth with autism spectrum disorders.” Biol Psychiatry, 2010;67(7):692–694.
- Meyer-Lindenberg A et al. “Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine.” Nat Rev Neurosci, 2011;12(9):524–538.
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My go-to source for Oxytocin 2mg. The oxytocin signaling improvements are consistent across batches which tells me QC is taken seriously.
Verified purchase — Ireland
Solid source. Oxytocin 2mg was packaged correctly and social bonding effects are exactly what the preclinical literature predicts. Verified purchase from Ireland.
Solid source. Oxytocin 2mg was packaged correctly and social bonding effects are exactly what the preclinical literature predicts. Verified purchase from Ireland.
Switched from a competitor to Decode for Oxytocin 2mg. Night and day difference in oxytocin signaling outcomes. Staying here permanently.
Verified purchase — Ireland
The Oxytocin 2mg quality is exceptional. Clear solution, correct lyophilized weight, and mood regulation effects started around day 10. Verified purchase from Ireland.
The Oxytocin 2mg quality is exceptional. Clear solution, correct lyophilized weight, and mood regulation effects started around day 10. Verified purchase from Ireland.
Oxytocin 2mg is decent quality but I have seen better mood regulation results with longer cycle durations. Purity seems fine. Verified purchase from Sweden.
Oxytocin 2mg is decent quality but I have seen better mood regulation results with longer cycle durations. Purity seems fine. Verified purchase from Sweden.
My go-to source for Oxytocin 2mg. The stress reduction improvements are consistent across batches which tells me QC is taken seriously. Verified purchase from New Zealand.
My go-to source for Oxytocin 2mg. The stress reduction improvements are consistent across batches which tells me QC is taken seriously. Verified purchase from New Zealand.
Fast dispatch, proper cold chain, and the Oxytocin 2mg reconstituted perfectly. Results speak for themselves — mood regulation is remarkable.
Verified purchase — Canada
Happy with my Oxytocin 2mg purchase. Shipping was fast and stress reduction protocol is progressing well. Great product overall. Verified purchase from New Zealand.
Happy with my Oxytocin 2mg purchase. Shipping was fast and stress reduction protocol is progressing well. Great product overall. Verified purchase from New Zealand.
Solid product overall. Oxytocin 2mg delivered on mood regulation within about 4-5 weeks. Packaging could be slightly better but quality is fine.
Verified purchase — Canada
Very good quality Oxytocin 2mg. mood regulation has been the main focus of my research and results are promising after 8 weeks.
Verified purchase — Finland
Product quality seems fine but Oxytocin 2mg took longer than expected to show mood regulation results. Will continue for another month.
Verified purchase — Australia
Good all round. Oxytocin 2mg appears to be dosed correctly based on observed mood regulation effects. Would buy again. Verified purchase from Germany.
Good all round. Oxytocin 2mg appears to be dosed correctly based on observed mood regulation effects. Would buy again. Verified purchase from Germany.
Oxytocin 2mg is decent quality but I’ve seen better trust response results with longer cycle durations. The purity seems fine.
Verified purchase — Singapore
Impressed by the professionalism. Oxytocin 2mg came with full COA, proper cold packaging, and stress reduction results are measurable. Verified purchase from Austria.
Impressed by the professionalism. Oxytocin 2mg came with full COA, proper cold packaging, and stress reduction results are measurable. Verified purchase from Austria.
Solid source. Oxytocin 2mg was packaged correctly and mood regulation effects are exactly what the preclinical literature predicts. Verified purchase from Canada.
Solid source. Oxytocin 2mg was packaged correctly and mood regulation effects are exactly what the preclinical literature predicts. Verified purchase from Canada.
Third order of Oxytocin 2mg and consistent quality every time. mood regulation is the main reason I keep coming back.
Verified purchase — Finland
Average experience with Oxytocin 2mg. trust response showed some improvement but nothing dramatic in my 4 week window.
Verified purchase — Austria
Fast dispatch, proper cold chain, and the Oxytocin 2mg reconstituted perfectly. Results speak for themselves — mood regulation is remarkable.
Verified purchase — Norway
Oxytocin 2mg exceeded my expectations. Noticed social bonding improvements within the first two weeks. Reordering immediately. Verified purchase from Italy.
Oxytocin 2mg exceeded my expectations. Noticed social bonding improvements within the first two weeks. Reordering immediately. Verified purchase from Italy.
Good experience with Oxytocin 2mg. social bonding improvements are noticeable though took a bit longer than expected. Quality is solid. Verified purchase from Spain.
Good experience with Oxytocin 2mg. social bonding improvements are noticeable though took a bit longer than expected. Quality is solid. Verified purchase from Spain.
Fast dispatch, proper cold chain, and the Oxytocin 2mg reconstituted perfectly. Results speak for themselves — oxytocin receptor signaling is remarkable.
Verified purchase — Sweden