Cognitive•Neuroprotective
🧠Cerebrolysin
Brain-derived neurotrophic peptide mixture approved in 50+ countries for Alzheimer's, stroke and TBI. Neurotrophic, neuroprotective and neuroregenerative effects mediated through BDNF, NGF and GDNF pathways.
Amino acids
Peptide mixture
Mol. weight
Variable (brain-derived)
Half-life
Variable
Availability
On inquiry
Amino acid sequence
Porcine brain-derived peptide mixture (<1 kDa fragments)What Is Cerebrolysin?
Cerebrolysin (EVER Neuro Pharma) is a peptide preparation derived from purified porcine brain proteins, containing low molecular weight neuropeptides (<1 kDa) and amino acids. Approved in 50+ countries for Alzheimer's disease, ischemic stroke, and traumatic brain injury. Mimics the effects of endogenous neurotrophic factors.
Key Mechanisms
- BDNF, NGF, GDNF mimicry — activates TrkB, TrkA and Ret receptor pathways — neurotrophic and neuroprotective
- Anti-apoptotic — reduces Bcl-2/Bax ratio favourably; prevents caspase-3 activation
- Neuroplasticity — promotes dendritic spine formation and synaptic strength
- Neurogenesis — stimulates hippocampal neurogenesis in aged models
- Neuroprotection — reduces glutamate excitotoxicity and oxidative damage post-ischemia
Key References
- Gauthier S et al. "Cerebrolysin in Alzheimer's disease." Eur J Neurol, 2003;10(6):595–601.
- Rockenstein E et al. "Cerebrolysin decreases amyloid-beta production." J Neurosci Res, 2006;83:1252–1261.
Related in Cognitive
🧠Cognitive Research
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HGF/MET signalling enhancer. Reported to be 7 orders of magnitude more potent than BDNF at inducing synaptogenesis. Blood-brain barrier penetrant. Used in dementia and cognitive decline research.
🧠Anxiolytic
Selank
Anxiolytic nootropic peptide developed in Russia. Modulates GABA-A, BDNF, and IL-6. Reduces anxiety without sedation or addiction potential. Approved in Russia for anxiety and phobia treatment.
🧠Nootropic
Semax
ACTH-derived nootropic peptide. Upregulates BDNF and NGF. Approved in Russia for ischemic stroke, TBI, optic nerve atrophy, and ADHD. Enhances memory, focus and neuroprotection.