Peptide Wiki
Complete scientific reference for 28+ research peptides — sequences, mechanisms, half-lives, stacking protocols and peer-reviewed citations.
🛡️ARA-290
Helix B surface peptide of erythropoietin. Activates the tissue-protective receptor (EPOR/βcR) without erythropoietic effects. In clinical trials for neuropathic pain in sarcoidosis. Potent anti-inflammatory.
🩹BPC-157
A 15-amino-acid peptide derived from human gastric juice with extraordinary multi-tissue healing properties. One of the most cited research peptides, with 200+ preclinical studies.
🧠Cerebrolysin
Brain-derived neurotrophic peptide mixture approved in 50+ countries for Alzheimer's, stroke and TBI. Neurotrophic, neuroprotective and neuroregenerative effects mediated through BDNF, NGF and GDNF pathways.
📈CJC-1295
Long-acting GHRH analogue. Stimulates pituitary GH release in pulses. Combined with Ipamorelin for synergistic GH secretion. DAC (Drug Affinity Complex) extends half-life from 30 min to 6–8 days.
🧠Dihexa
HGF/MET signalling enhancer. Reported to be 7 orders of magnitude more potent than BDNF at inducing synaptogenesis. Blood-brain barrier penetrant. Used in dementia and cognitive decline research.
🌙DSIP (Delta Sleep-Inducing Peptide)
Endogenous nonapeptide that induces delta (slow-wave) sleep. Modulates stress response, reduces cortisol, normalises circadian disruptions and has potential applications in insomnia and PTSD research.
🧬Epithalon (Epitalon)
Tetrapeptide derived from pineal gland extract that directly activates telomerase (hTERT), extending telomeres and reversing cellular senescence. 30+ years of peer-reviewed research.
🩹GHK-Cu (Copper Peptide)
Copper tripeptide that modulates 32% of the human genome. The most wide-ranging regenerative peptide for ECM remodelling, wound healing, hair growth and neural repair.
🛡️HCG (Human Chorionic Gonadotropin)
LH-receptor agonist glycoprotein hormone. The gold-standard research tool for Leydig cell steroidogenesis, ovarian function, HPG axis regulation and IVF research.
📈HGH Somatropin
Recombinant human growth hormone (191 aa). The upstream GH/IGF-1 axis activator. FDA-approved since 1985. Drives body composition, bone density, wound healing and metabolic function via JAK2/STAT5b.
📈IGF-1 LR3
Long-acting IGF-1 analogue with 20–30h half-life. Activates mTORC1, suppresses FOXO atrophy genes, and drives satellite cell proliferation. 1000× reduced IGFBP binding vs native IGF-1.
📈Ipamorelin
Selective GH secretagogue. Stimulates GH release without elevating cortisol or prolactin — cleaner GH stimulus than older GHRPs. Stack with CJC-1295 for synergistic GH amplification.
🛡️Kisspeptin-10
Hypothalamic neuropeptide that drives GnRH pulsatile release — the master upstream regulator of the HPG axis. Critical for puberty onset and fertility. Used in hypogonadism and fertility research.
🛡️LL-37 (Cathelicidin)
The only human cathelicidin. Broad-spectrum antimicrobial, anti-biofilm, and wound healing peptide. Also modulates innate immunity, promotes angiogenesis and accelerates skin wound closure.
💊Melanotan II
Non-selective melanocortin receptor agonist (MC1R–MC5R). Precursor to PT-141 (bremelanotide). Promotes melanogenesis, sexual arousal, and appetite suppression. Extensive preclinical and human data.
⚖️MOTS-C
Mitochondria-encoded exercise mimetic peptide. Activates AMPK via AICAR, improves insulin sensitivity and drives fat oxidation — independently of insulin receptor signalling.
🧬NAD+ (Nicotinamide Adenine Dinucleotide)
The central electron carrier of cellular metabolism and obligate substrate for sirtuins (SIRT1–7), PARPs, and CD38. Declines 50% between ages 40–60.
💊Oxytocin
Nonapeptide governing social bonding, trust, pair bonding, arousal, and reproductive function. Primary research tool for social neuroscience, ASD, PTSD, and attachment biology.
💊PT-141 (Bremelanotide)
FDA-approved (Vyleesi, 2019) CNS melanocortin receptor agonist. Acts via MC3R/MC4R in hypothalamus — not peripherally. Effective in PDE5 non-responders.
⚖️Retatrutide (LY3437943)
Triple GIP/GLP-1/glucagon receptor agonist. Phase II trial demonstrated 24.2% body weight reduction at 48 weeks — the highest ever recorded for a pharmacological agent.
🧠Selank
Anxiolytic nootropic peptide developed in Russia. Modulates GABA-A, BDNF, and IL-6. Reduces anxiety without sedation or addiction potential. Approved in Russia for anxiety and phobia treatment.
⚖️Semaglutide
GLP-1 receptor agonist. FDA-approved (Ozempic/Wegovy). Up to 15% weight loss in Phase III trials. Reduces cardiovascular events (SELECT trial). The benchmark for GLP-1 weight loss research.
🧠Semax
ACTH-derived nootropic peptide. Upregulates BDNF and NGF. Approved in Russia for ischemic stroke, TBI, optic nerve atrophy, and ADHD. Enhances memory, focus and neuroprotection.
🧬SS-31 (Elamipretide)
Szeto-Schiller tetrapeptide. Targets cardiolipin on the inner mitochondrial membrane. Restores mitochondrial cristae architecture, reduces ROS, and dramatically improves ETC function. In clinical trials for HFrEF and Barth syndrome.
🩹TB500 (Thymosin Beta-4)
Synthetic Thymosin Beta-4 analogue. Drives angiogenesis, G-actin sequestration and cell migration — the cornerstone of systemic tissue repair research.
🛡️Thymosin Alpha-1 (Tα1)
Thymic peptide and potent immune system modulator. FDA-approved (Zadaxin) in 37 countries for hepatitis B, hepatitis C, and immunodeficiency. Activates dendritic cells, NK cells and Th1 response.
⚖️Tirzepatide
FDA-approved dual GIP/GLP-1 receptor agonist (Mounjaro/Zepbound). Up to 22.5% weight loss in SURMOUNT-1 trial. Currently the most effective approved anti-obesity medication.
🛡️VIP (Vasoactive Intestinal Peptide)
Endogenous neuropeptide with potent immunomodulatory, anti-inflammatory, and vasodilatory properties. Regulates circadian biology, gut motility, and T-regulatory cell activity. Used in autoimmunity, CIRS, and long COVID research.