Decode Peptides
Growth Hormone•FDA Approved

📈HGH Somatropin

Recombinant human growth hormone (191 aa). The upstream GH/IGF-1 axis activator. FDA-approved since 1985. Drives body composition, bone density, wound healing and metabolic function via JAK2/STAT5b.

Amino acids
191
Mol. weight
22,124 Da
Half-life
~4 hours (SC)
Availability
In stock
Amino acid sequence
191-amino acid single chain

What Is HGH Somatropin?

Human Growth Hormone (HGH / somatropin) is a 191-amino-acid single-chain polypeptide secreted by somatotroph cells of the anterior pituitary. Recombinant HGH (rHGH) has been FDA-approved since 1985 for GHD, Turner syndrome, Prader-Willi syndrome, CKD, and AIDS-related wasting.

Key Mechanisms

  • JAK2 / STAT5b — primary signalling cascade driving hepatic IGF-1 production
  • MAPK / ERK — cell proliferation, differentiation, anti-apoptotic effects
  • PI3K / Akt / mTOR — protein synthesis, glucose uptake, cell survival
  • Direct lipolysis — HSL activation in adipocytes shifts substrate use toward FFA

Research Applications

  • GH/IGF-1 axis biology and body composition
  • Bone density and osteoblast biology
  • Wound healing and burn injury recovery
  • Aging and anti-aging marker research
  • Metabolic syndrome models

Key References

  1. Rudman D et al. "Effects of HGH in men over 60 years old." N Engl J Med, 1990;323:1–6.
  2. Jorgensen JO et al. "Beneficial effects of GH treatment in GH-deficient adults." Lancet, 1989;1:1221–1225.

Related in Growth Hormone

📈GHRH Analogue
CJC-1295
Long-acting GHRH analogue. Stimulates pituitary GH release in pulses. Combined with Ipamorelin for synergistic GH secretion. DAC (Drug Affinity Complex) extends half-life from 30 min to 6–8 days.
📈Anabolic Effector
IGF-1 LR3
Long-acting IGF-1 analogue with 20–30h half-life. Activates mTORC1, suppresses FOXO atrophy genes, and drives satellite cell proliferation. 1000× reduced IGFBP binding vs native IGF-1.
📈Selective GHRP
Ipamorelin
Selective GH secretagogue. Stimulates GH release without elevating cortisol or prolactin — cleaner GH stimulus than older GHRPs. Stack with CJC-1295 for synergistic GH amplification.