Decode Peptides
Growth Hormone•GHRH Analogue

📈CJC-1295

Long-acting GHRH analogue. Stimulates pituitary GH release in pulses. Combined with Ipamorelin for synergistic GH secretion. DAC (Drug Affinity Complex) extends half-life from 30 min to 6–8 days.

Amino acids
30
Mol. weight
3647.9 Da
Half-life
6–8 days (DAC form)
Availability
On inquiry
Amino acid sequence
GHRH analogue with DAC technology

What Is CJC-1295?

CJC-1295 is a tetrasubstituted analogue of GHRH(1-29) with additional modifications including a Drug Affinity Complex (DAC) — a maleimide-modified lysine that covalently binds serum albumin, extending half-life from ~30 minutes to 6–8 days. It stimulates pituitary GH release by binding GHRHR.

Key Mechanisms

  • GHRHR agonism — stimulates pituitary somatotroph cells to release GH in physiological pulses
  • Sustained GH elevation — DAC technology enables once-weekly dosing while preserving pulsatile release
  • IGF-1 induction — elevated GH drives hepatic IGF-1 production via JAK2/STAT5b

Stacking

Most commonly combined with Ipamorelin — CJC-1295 amplifies GH pulse amplitude (GHRH pathway) while Ipamorelin increases GH pulse frequency (GHSR/ghrelin pathway) without cortisol/prolactin elevation.

Key References

  1. Teichman SL et al. "Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295." J Clin Endocrinol Metab, 2006;91:799–805.

Related in Growth Hormone

📈FDA Approved
HGH Somatropin
Recombinant human growth hormone (191 aa). The upstream GH/IGF-1 axis activator. FDA-approved since 1985. Drives body composition, bone density, wound healing and metabolic function via JAK2/STAT5b.
📈Anabolic Effector
IGF-1 LR3
Long-acting IGF-1 analogue with 20–30h half-life. Activates mTORC1, suppresses FOXO atrophy genes, and drives satellite cell proliferation. 1000× reduced IGFBP binding vs native IGF-1.
📈Selective GHRP
Ipamorelin
Selective GH secretagogue. Stimulates GH release without elevating cortisol or prolactin — cleaner GH stimulus than older GHRPs. Stack with CJC-1295 for synergistic GH amplification.