📈Ipamorelin
Selective GH secretagogue. Stimulates GH release without elevating cortisol or prolactin — cleaner GH stimulus than older GHRPs. Stack with CJC-1295 for synergistic GH amplification.
Aib-His-D-2Nal-D-Phe-Lys-NH₂What Is Ipamorelin?
Ipamorelin is a selective pentapeptide growth hormone releasing peptide (GHRP) that agonises the GHSR-1a (ghrelin receptor) in the pituitary and hypothalamus. Unlike GHRP-6 and GHRP-2, ipamorelin does not significantly elevate cortisol, ACTH, or prolactin — making it the cleanest GHRP for research use.
Key Mechanisms
- GHSR-1a agonism — stimulates pituitary GH secretion in a dose-dependent manner
- Pulse frequency increase — increases the frequency of natural GH pulses without disrupting the pulsatile pattern
- Ghrelin-independent selectivity — no significant cortisol or prolactin release at research doses
Key References
- Raun K et al. "Ipamorelin, the first selective growth hormone secretagogue." Eur J Endocrinol, 1998;139:552–561.
Frequently Asked Questions
Research comparing GHRPs found that Ipamorelin stimulates GH release with minimal to no effect on cortisol, prolactin, or appetite (ghrelin-like) signalling — effects that older secretagogues such as GHRP-6 and GHRP-2 do produce.
No — it's active as a standalone GHSR-1a agonist, but the two are frequently studied together because they engage separate GH-release pathways (ghrelin receptor vs GHRH receptor), which researchers use to probe additive or synergistic pulse effects.
As with most short peptides, refrigerate at 2–8°C after reconstitution and use within 28 days; the unreconstituted lyophilized powder is considerably more stable for storage.