CJC-1295 Without DAC 5mg
CJC-1295 without DAC (Mod GRF 1-29) is a tetra-substituted 29-amino-acid GHRH analogue used to study short, pulsatile GH release. This research vial contains 5mg, ≥99% HPLC purity.
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COA with every batch
Independent EU lab, ≥99% HPLC
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About this compound
What Is CJC-1295 Without DAC?
CJC-1295 without DAC — commonly referenced as Mod GRF (1-29) — is a 29-amino-acid analogue of the bioactive fragment of growth-hormone-releasing hormone. Four amino-acid substitutions (D-Ala², Gln⁸, Ala¹⁵, Leu²⁷) protect it against DPP-4 cleavage and trypsin digestion while preserving full GHRH receptor affinity.
Without DAC vs. With DAC
The Drug Affinity Complex (DAC) is a maleimide group that binds serum albumin and stretches the half-life to roughly 6–8 days, producing a sustained "bleed" of growth hormone. Without DAC, the half-life is around 30 minutes — which keeps GH release sharply pulsatile and much closer to natural secretory physiology. That makes this form the standard choice for research into pulse amplitude rather than total GH exposure.
Key Mechanisms
- GHRH receptor agonism — stimulates anterior-pituitary somatotrophs to release stored growth hormone
- Pulse amplification — raises the height of existing GH pulses rather than creating continuous elevation
- DPP-4 resistance — the D-Ala² substitution blocks the primary degradation site
- GHRP synergy — combined with a ghrelin-receptor agonist, GH output exceeds the sum of either alone
Research Applications
- GH pulsatility and secretory-dynamics studies
- GH/IGF-1 axis pharmacology
- Body-composition and recovery models
- Synergy studies with Ipamorelin or other GHRPs
Handling
Supplied lyophilized. Reconstitute with bacteriostatic water. Store the sealed vial at 2–8 °C; refrigerate after reconstitution and use within 28 days.
Supplied strictly for laboratory and in-vitro research use only. Not for human or veterinary use, not for consumption.
Specifications
- Sequence
- Mod GRF (1-29) — D-Ala², Gln⁸, Ala¹⁵, Leu²⁷
- Molecular Weight
- 3367.9 Da
- Amino Acids
- 29
- Half-Life
- ~30 minutes
- Vial Size
- 5mg
- Purity
- ≥99% (HPLC)
- Form
- Lyophilized powder
- Reconstitution
- Bacteriostatic water (0.9% benzyl alcohol)
- Storage
- Sealed: 2–8 °C · Reconstituted: 2–8 °C, use within 28 days
Research library
Full mechanism breakdowns and peer-reviewed references for this compound.
Frequently asked questions
Related research compounds
For laboratory and in-vitro research use only. Not for human or veterinary use, not for consumption. By purchasing, you confirm you are a qualified researcher and accept full responsibility for compliant handling and disposal. Read the full disclaimers.