Epithalon (Epitalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) developed from the natural pineal peptide Epithalamin. It is one of the most extensively researched anti-aging peptides, studied primarily for its ability to stimulate telomerase activity, elongate telomeres, and regulate circadian rhythms. Each vial contains 10mg of research-grade Epithalon.
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About this compound
Epithalon (tetrapeptide Ala-Glu-Asp-Gly) was developed by Professor Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology from pineal gland extract. It is one of the best-documented anti-aging peptides in the world, with over 30 years of peer-reviewed research demonstrating direct telomerase activation, epigenetic reprogramming of senescent cells, melatonin restoration, and significant lifespan extension in multiple model organisms. Its ability to increase telomere length in human somatic cells makes it the leading research tool for telomere biology and biological age reversal studies.
Research Data
Research Snapshot — Epithalon
Key Mechanisms & Pathways
- Telomerase (hTERT) ActivationDirectly upregulates telomerase, extending telomeric DNA repeats and reversing cellular senescence.
- Pineal Gland NormalisationRestores melatonin synthesis in aged pinealocytes, resetting circadian and immune regulation.
- Antioxidant Gene UpregulationIncreases SOD, catalase and glutathione peroxidase — the primary enzymatic antioxidant defence system.
- Epigenetic ReprogrammingReactivates methylation-silenced tumour suppressor genes p16 and p21.
- Neuroendocrine Axis ResetRestores hypothalamic receptor sensitivity to sex steroid feedback, normalising age-related hormonal decline.
- NK Cell ActivationEnhanced natural killer cell cytotoxicity and restored thymic activity in aged rodent models.
Preclinical & Clinical Research Summary
| Research Area | Key Finding | Source |
|---|---|---|
| Telomere Elongation | +42% replicative lifespan of human fetal fibroblasts vs. controls via hTERT activation. | Khavinson et al., 2003 — Bull Exp Biol Med |
| Lifespan Extension | Extended Drosophila mean lifespan by 11–16%; maximum lifespan by 13%. | Khavinson et al., 2000 — Bull Exp Biol Med |
| Cancer Prevention | Reduced spontaneous mammary tumour incidence by 2.4× in HER2-transgenic mice. | Anisimov VN et al., 2003 — Biogerontology |
| Cardiovascular | Reduced cardiovascular mortality in 12-year longitudinal study of elderly patients. | Khavinson et al., 2012 — Gerontology |
References
- Khavinson VKh et al. "Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells." Bull Exp Biol Med, 2003;135(6):590–592.
- Anisimov VN et al. "Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence." Biogerontology, 2003;4(4):193–202.
- Kossoy G et al. "Effect of epithalon on the lifespan and frequency of spontaneous mammary gland tumors in transgenic HER2 mice." Neoplasma, 2006;53(3):187–192.
- Khavinson V et al. "Tetrapeptide AEDG (Epitalon) inhibits oxidative stress." Regul Toxicol Pharmacol, 2014;70(1):289–294.
Specifications
- Sequence
- Ala-Glu-Asp-Gly (AEDG)
- Molecular Weight
- 390.4 Da
- Amino Acids
- 4
- Half-Life
- 2–4 hours
- CAS Number
- 307297-39-8
- Vial Size
- 10mg
- Purity
- ≥99% (HPLC)
- Form
- Lyophilized powder
- Reconstitution
- Bacteriostatic water (0.9% benzyl alcohol)
- Storage
- Sealed: 2–8 °C · Reconstituted: 2–8 °C, use within 28 days
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