NAD+ 500mg
NAD+ (nicotinamide adenine dinucleotide) is the central redox coenzyme of cellular metabolism and the obligate substrate for sirtuins and PARPs. High-capacity 500mg research vial, ≥99% HPLC purity.
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COA with every batch
Independent EU lab, ≥99% HPLC
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Plain outer box, no branding
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About this compound
What Is NAD+?
NAD+ (nicotinamide adenine dinucleotide) is a pyridine dinucleotide coenzyme present in every living cell. It shuttles electrons between the reactions of glycolysis, the TCA cycle and oxidative phosphorylation, and it is consumed as a substrate — not merely used as a cofactor — by the sirtuin deacylases, PARP DNA-repair enzymes and CD38. Cellular NAD+ concentrations decline measurably with age, which is why the molecule sits at the centre of longevity research.
Key Mechanisms
- Redox carrier — the NAD+/NADH couple drives mitochondrial ATP production
- Sirtuin substrate — SIRT1–7 require NAD+ for deacetylation of histones, PGC-1α, FOXO and p53
- PARP-mediated DNA repair — PARP1 consumes NAD+ when repairing single-strand breaks
- CD38 regulation — the principal NAD+-degrading ectoenzyme, whose activity rises with age
Why the 500mg Format
This vial carries 500mg of NAD+ disodium salt, roughly 2.5× the 200mg format, for protocols that require larger working volumes or repeated preparations from a single vial. Composition and purity are identical to the 200mg presentation.
Research Applications
- Cellular senescence and ageing models
- Mitochondrial function and bioenergetics
- Sirtuin and PARP enzymology
- Metabolic stress and neuroprotection studies
Handling
Supplied lyophilized. NAD+ is hygroscopic and light-sensitive. Store the sealed vial at 2–8 °C protected from light; refrigerate after reconstitution and use promptly.
Supplied strictly for laboratory and in-vitro research use only. Not for human or veterinary use, not for consumption.
Specifications
- Sequence
- Dinucleotide coenzyme
- Molecular Weight
- 663.4 Da
- Half-Life
- Minutes (direct administration)
- CAS Number
- 53-84-9
- Vial Size
- 500mg
- Purity
- ≥99% (HPLC)
- Form
- Lyophilized powder
- Reconstitution
- Bacteriostatic water (0.9% benzyl alcohol)
- Storage
- Sealed: 2–8 °C · Reconstituted: 2–8 °C, use within 28 days
Research library
Full mechanism breakdowns and peer-reviewed references for this compound.
Frequently asked questions
Related research compounds
For laboratory and in-vitro research use only. Not for human or veterinary use, not for consumption. By purchasing, you confirm you are a qualified researcher and accept full responsibility for compliant handling and disposal. Read the full disclaimers.